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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by metafunj on September 21, 2009, at 16:43:16
SSRIs can cause a host of negative effects through indirect agonism of certain serotonin receptors. Agonizing the 5 HT1A, 5HT2A/C, and 5HT3 receptors can cause problems such like sleep disturbance, anhedonia, sexual dysfunction, and nausea.
Which adrenic receptors exert negative effects when indirectly agonized by NRI?
Which cause dry mouth, constipation, jumpiness, seizures, etc.
The fact that antagonizing certain adrenic receptors creates a theraputic effect would indicate that agonism can have a negative effect.
Posted by Brainbeard on October 3, 2009, at 16:12:39
In reply to What are the negative effects of NRI?, posted by metafunj on September 21, 2009, at 16:43:16
One correction: (indirect) agonism of the 5HT1A receptor is thought to be one of the essential mechanisms of most antidepressants.
Well, I have to add this: the indirect agonism of 5HT2A and -C receptors of SSRI's eventually leads to downregulation of these receptors, which indirectly yields results that may come close to direct antagonism. The weight gain so often seen with the SSRI's, for instance, may well be the result of 5HT2C receptors downregulation.
Then - I don't know s h i t about noradrenergic receptors. I do know that some of the most obvious possible side-effects of noradrenergic meds are irritability and problems with peeing. Also, NRI's can cause sleepiness, oddly enough.
Wanna know everything about noradrenergic subtype receptors, and that placed in historical perspective? Go here: http://www.acnp.org/G4/GN401000034/CH034.html
Posted by metafunj on October 6, 2009, at 21:09:12
In reply to Re: What are the negative effects of NRI?, posted by Brainbeard on October 3, 2009, at 16:12:39
Interesting. Seems like indirectly agonizing some of those receptors would eventually decrease anxiety but increase in other cases. I wonder how much of NRIs positive effects come from its blocking dopamine reuptake in the PFC?
Posted by Brainbeard on October 7, 2009, at 14:06:40
In reply to Re: What are the negative effects of NRI? » Brainbeard, posted by metafunj on October 6, 2009, at 21:09:12
> Interesting. Seems like indirectly agonizing some of those receptors would eventually decrease anxiety but increase in other cases. I wonder how much of NRIs positive effects come from its blocking dopamine reuptake in the PFC?
Our friend Dr. Stephen Stahl seems to reckon with a significant contribution.
Posted by desolationrower on October 22, 2009, at 1:04:59
In reply to Re: What are the negative effects of NRI?, posted by Brainbeard on October 7, 2009, at 14:06:40
depends on the type of anxiety, the mostly help panic type, not ruminations or OCD. the pfc stuff could help if add->anxiety
-d/r
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