Posted by Brainbeard on October 3, 2009, at 16:12:39
In reply to What are the negative effects of NRI?, posted by metafunj on September 21, 2009, at 16:43:16
One correction: (indirect) agonism of the 5HT1A receptor is thought to be one of the essential mechanisms of most antidepressants.
Well, I have to add this: the indirect agonism of 5HT2A and -C receptors of SSRI's eventually leads to downregulation of these receptors, which indirectly yields results that may come close to direct antagonism. The weight gain so often seen with the SSRI's, for instance, may well be the result of 5HT2C receptors downregulation.
Then - I don't know s h i t about noradrenergic receptors. I do know that some of the most obvious possible side-effects of noradrenergic meds are irritability and problems with peeing. Also, NRI's can cause sleepiness, oddly enough.
Wanna know everything about noradrenergic subtype receptors, and that placed in historical perspective? Go here: http://www.acnp.org/G4/GN401000034/CH034.html
poster:Brainbeard
thread:917964
URL: http://www.dr-bob.org/babble/neuro/20090701/msgs/919575.html