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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by SheilaC on July 31, 2009, at 16:09:33
The thought never occurred to me that maybe the daytime crabbiness was due to the nighttime dose of Seroquel wearing off. Could that be why I get anxious and irritable during the day?
Someone mentioned taking a small dose of Seroquel during the day as well. I've never taken it during the day.
Wouldn't daytime Seroquel make me sleepy?
I'm looking for a little motivation not sleepiness.
Posted by Frustratedmama on August 1, 2009, at 8:04:20
In reply to SLS + Brainbread, question..., posted by SheilaC on July 31, 2009, at 16:09:33
Isnt there a new long acting seroquel now? Have you tried that? Just trying to help....not nearly as knowledgeable as the others....good luck!
Posted by SheilaC on August 1, 2009, at 13:36:17
In reply to Re: SLS + Brainbread, question..., posted by Frustratedmama on August 1, 2009, at 8:04:20
> Isnt there a new long acting seroquel now? Have you tried that? Just trying to help....not nearly as knowledgeable as the others....good luck!
I haven't tried that, but I may mention it to my doc. That could work. Right now the Seroquel works really well for sleep.
Posted by Brainbeard on September 8, 2009, at 11:38:28
In reply to SLS + Brainbread, question..., posted by SheilaC on July 31, 2009, at 16:09:33
From what I remember, Seroquel (quetiapine) has a bizarrely phased out effect, where you can get sort of a dopamine rebound effect so many hours after a single dose that could be the cause of the symptoms you describe.
What do you take Seroquel for? If you're looking for motivation, Seroquel seems an awkward choice.
Personally, I don't really understand what good Seroquel is anyway. It sedates the hell out of you, that seems to be what it does mostly. It's not a very impressive antipsychotic for all I know. It performs poorly as an augmentation to other meds. I think there are better choices if you're looking for sedation. But are you?!
Posted by sowhysosad on September 15, 2009, at 21:42:32
In reply to SLS + Brainbread, question..., posted by SheilaC on July 31, 2009, at 16:09:33
I've tried "topping up" with 12.5mg of Seroquel during the day.
Whilst it does suppress crabbiness or irritation, I also feel drowsy, unmotivated, withdrawn and a little depressed.
> The thought never occurred to me that maybe the daytime crabbiness was due to the nighttime dose of Seroquel wearing off. Could that be why I get anxious and irritable during the day?
>
> Someone mentioned taking a small dose of Seroquel during the day as well. I've never taken it during the day.
>
> Wouldn't daytime Seroquel make me sleepy?
>
> I'm looking for a little motivation not sleepiness.
Posted by sowhysosad on September 15, 2009, at 21:50:14
In reply to Re: SLS + Brainbread, question..., posted by Brainbeard on September 8, 2009, at 11:38:28
> From what I remember, Seroquel (quetiapine) has a bizarrely phased out effect, where you can get sort of a dopamine rebound effect so many hours after a single dose that could be the cause of the symptoms you describe.
That's really interesting. Do you have any more information on that?
I do know it has a fairly low D2 receptor occupancy half-life in the nigrostriatal pathway - only around 10 hours. They think that's why it rarely causes TD.
I'm taking low-dose Seroquel and trying to work out what the heck's going on with dopamine in my brain.
> I think there are better choices if you're looking for sedation.
I'm not even supposed to be taking it for sleep, but it's so much better than mirtazapine in that respect because it doesn't leave me particularly drowsy the following day.
Probably less addictive than benzos for sleep/sedation too.
Posted by Brainbeard on September 16, 2009, at 8:26:14
In reply to Re: SLS + Brainbread, question... » Brainbeard, posted by sowhysosad on September 15, 2009, at 21:50:14
> > From what I remember, Seroquel (quetiapine) has a bizarrely phased out effect, where you can get sort of a dopamine rebound effect so many hours after a single dose that could be the cause of the symptoms you describe.
>
> That's really interesting. Do you have any more information on that?
Not at hand, it's what I've gathered from searching forums about Seroquel. I just remember that kind of information, I don't bookmark it or anything (perhaps I should. I do use a social bookmarking system.)
Posted by g_g_g_unit on September 17, 2009, at 22:42:03
In reply to Re: SLS + Brainbread, question..., posted by Brainbeard on September 8, 2009, at 11:38:28
>I think there are better choices if you're >looking for sedation. But are you?!
what would you suggest? the first week i spent on parnate at 10mgs, where i could sleep on my own, i felt perky and occasionally euphoric. now that i'm at 20mg (and today 30mg) and using Seroquel to sleep, i often feel crabby during the day. i had assumed it was the stimulation from the Parnate, but maybe it's the Seroquel wearing off, as you guys described. i think since i have anhedonia + executive function issues, i need all the dopamine i can get.
Posted by Brainbeard on September 18, 2009, at 7:36:44
In reply to Re: SLS + Brainbread, question..., posted by g_g_g_unit on September 17, 2009, at 22:42:03
> >I think there are better choices if you're >looking for sedation. But are you?!
>
> what would you suggest?Well, low dose nortriptyline might work for you. It's got moderate antihistaminergic action, but also moderate 5HT2A-antagonism, which can promote healthy sleeping patterns. Then it's also a pro-dopaminergic drug, indirectly through noradrenaline reuptake inhibition as well as the 5HT2A-antagonism. A dose somewhere between 25 and 75mg might help. It could give you a bit of dry mouth. It has helped me before with sleep, although it did make me a little bit edgy in the daytime, especially in the beginning of treatment.
Many NRI's seem to do that for me.
Posted by metafunj on September 18, 2009, at 18:20:25
In reply to Re: SLS + Brainbread, question..., posted by g_g_g_unit on September 17, 2009, at 22:42:03
So why can't you just go back to 10 mgs Parnate and drop the Seroquel? Do you need an AP?
Sounds like you were getting better on that dosage of Parnate.
Posted by g_g_g_unit on September 19, 2009, at 7:11:45
In reply to Re: SLS + Brainbread, question... » g_g_g_unit, posted by metafunj on September 18, 2009, at 18:20:25
> So why can't you just go back to 10 mgs Parnate and drop the Seroquel? Do you need an AP?
>
> Sounds like you were getting better on that dosage of Parnate.it wasn't a true AD effect - just a temporary euphoria that disappeared after a week. i did ditch the Seroquel last night and took Zopiclone instead; i feel a bit stranded though because the Zopiclone isn't a long-term solution and my psych won't titrate past 30mg, where i might sleep better, or add a TCA.
i actually have a box of amitriptyline at home. i'm thinking of finding a new psych more experienced in MAOI's. in the meantime, would there be any significant risk in adding 20mg of the amitrip to allow for better sleep? i realise it's incredibly stupid to self-medicate, but i have been on so much stuff and have to let the Parnate work, which won't happen without sleep.
This is the end of the thread.
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