Posted by sowhysosad on September 15, 2009, at 21:50:14
In reply to Re: SLS + Brainbread, question..., posted by Brainbeard on September 8, 2009, at 11:38:28
> From what I remember, Seroquel (quetiapine) has a bizarrely phased out effect, where you can get sort of a dopamine rebound effect so many hours after a single dose that could be the cause of the symptoms you describe.
That's really interesting. Do you have any more information on that?
I do know it has a fairly low D2 receptor occupancy half-life in the nigrostriatal pathway - only around 10 hours. They think that's why it rarely causes TD.
I'm taking low-dose Seroquel and trying to work out what the heck's going on with dopamine in my brain.
> I think there are better choices if you're looking for sedation.
I'm not even supposed to be taking it for sleep, but it's so much better than mirtazapine in that respect because it doesn't leave me particularly drowsy the following day.
Probably less addictive than benzos for sleep/sedation too.
poster:sowhysosad
thread:909483
URL: http://www.dr-bob.org/babble/neuro/20090701/msgs/917307.html