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Dr. Bob is Robert Hsiung, MD,
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Posted by TriedEveryDrug on June 6, 2009, at 22:23:47
I have inflammatory bowel disease. Some drugs appear to make me have flare-ups. Remeron does this to me. Others, like desipramine reduce my symptoms.
I just noticed this on wikipedia about the 5-HT2A receptor:"Other 5-HT2A agonists like LSD also have potent anti-inflammatory effects against TNF-alpha induced inflammation."
Well, TNF (tumor necrosis factor) is targeted by the latest crohn's drugs.
And sure enough, mirtazipine is a 5-HT2A antagonist.
Case closed?
(though this doesn't explain why effexor/pristiq make my crohn's worse but not as bad as remeron - I don't see anything written about them and 5-HT2a blocking action)
Posted by desolationrower on June 7, 2009, at 6:16:31
In reply to Why some psych drugs make my Crohn's worse, posted by TriedEveryDrug on June 6, 2009, at 22:23:47
not 100% but i think ssris decrease peripheral serotonin
-d/r
Posted by SLS on June 8, 2009, at 5:28:31
In reply to Re: Why some psych drugs make my Crohn's worse, posted by desolationrower on June 7, 2009, at 6:16:31
> not 100% but i think ssris decrease peripheral serotonin
SRIs do bind to blood platelets and inhibit serotonins uptake, I believe. I don't know the ramifications this has on blood levels, though.
- Scott
This is the end of the thread.
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