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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by iforgotmypassword on April 27, 2008, at 16:24:25
Of course, I mean in relation to the method of doing so via inhibition of MAO-B in the brain.
Abstracts briefly endorse safety, and I have no access to possible elaboration that there may be in full-texts, however has ANYONE come across anything that would fully explain that chronic unmoderated PEA activity in the brain is, or must logically be: **completely safe.** (?)
Any reasoning behind simply regarding it as safe? SSRIs prevent the moderation of serotonin, which as we have discovered can be harmful. Increasing PEA through exogenous sources and inhibiting it's moderation may not, in future, prove to be a similar case? After all, our documented experience with this combination is sparse, and it took us forever to articulate that YES, SSRIs are hurting people.
This, obviously, but for clarification is about the selegiline DLPA or similar brain PEA level increasing and preserving combinations.
I am willing to try anything at this point, but that's what made me turn to Paxil years upon years ago and I still regret it, and it didn't even help me. (However selegiline DLPA might. **Hard to balance.**)
Posted by iforgotmypassword on April 28, 2008, at 16:47:46
In reply to Is it established as safe to flood brain with PEA?, posted by iforgotmypassword on April 27, 2008, at 16:24:25
looks like, from an earlier thread this year and some others, that it does indeed carry risk. and one person reported poop-out.
i've given amantadine a fair trial now, i am pretty sure, and i'm even worse.
i don't know where i can go from here...
Posted by undopaminergic on May 1, 2008, at 7:20:02
In reply to Is it established as safe to flood brain with PEA?, posted by iforgotmypassword on April 27, 2008, at 16:24:25
PEA has striking similarities to amphetamines, and share at least some of the risks associated with the latter - theoretically, this may include potential neurotoxicity, but I haven't seen any research that confirms this.
As with amphetamines, PEA dose-dependently elevates blood pressure, may elicit stereotypical behaviours and other psychiatric effects, and can produce various degrees of tolerance and other neurophysiological adaptions, whether beneficial or detrimental.
Like amphetamines, PEA can be a valuable psyhcopharmacological tool when used properly, and harmful if used recklessly.
Posted by BrightEyed+Blueberry on May 7, 2008, at 22:43:47
In reply to Re: Is it established as safe to flood brain with PEA?, posted by undopaminergic on May 1, 2008, at 7:20:02
Might these links help? I think I picked them up from a previous post here. You only have to sign in to BJSM Online once, for free, and the article there has at least 2 relevant links (dated 1995-96) to
1)Phenylethylamine
Modulation of Affect:
Therapeutic and
Diagnostic Implications
Hector C. Sabelli, M.D., Ph.D.
Javaid I.and
2)Sustained
Antidepressant Effect of
PEA Replacement
Hector Sabelli, M.D., Ph.D., D.H.C.
Peter Fink, M.D.
Jan Fawcett, M.D.
Cynthia Tom, B.S.
Downloaded from bjsm.bmj.com on 28 January 2008Phenylethylamine, a possible link to the
antidepressant effects of exercise?A Szabo, E Billett and J Turner
Br. J. Sports Med. 2001;35;342-343
doi:10.1136/bjsm.35.5.342Updated information and services can be found at:
http://bjsm.bmj.com/cgi/content/full/35/5/342
These include:
References This article cites 4 articles, 2 of which can be accessed free at:
http://bjsm.bmj.com/cgi/content/full/35/5/342#BIBL
1 online articles that cite this article can be accessed at:
http://bjsm.bmj.com/cgi/content/full/35/5/342#otherarticles
-Bright
***> PEA has striking similarities to amphetamines, and share at least some of the risks associated with the latter - theoretically, this may include potential neurotoxicity, but I haven't seen any research that confirms this.
>
> As with amphetamines, PEA dose-dependently elevates blood pressure, may elicit stereotypical behaviours and other psychiatric effects, and can produce various degrees of tolerance and other neurophysiological adaptions, whether beneficial or detrimental.
>
> Like amphetamines, PEA can be a valuable psyhcopharmacological tool when used properly, and harmful if used recklessly.
This is the end of the thread.
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Dr. Bob is Robert Hsiung, MD,
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