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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by SLS on July 7, 2022, at 7:20:44
Can anyone describe their personal experience using quetiapine (Seroquel) as a hypnotic (sleep-aid)?
1. Quality of sleep
- Falling asleep (Sleep initiation)?
- Staying asleep? (Sleep maintenance)?2. Maintained efficacy over months or years?
3. What dosage?
4. The mechanism most responsible for Seroquel inducing sleep?
.
Thanks much for any help people can offer.
- Scott
Posted by PeterMartin on July 8, 2022, at 18:22:06
In reply to Quetiapine / Seroquel for sleep?, posted by SLS on July 7, 2022, at 7:20:44
> Can anyone describe their personal experience using quetiapine (Seroquel) as a hypnotic (sleep-aid)?
>
> 1. Quality of sleep
> - Falling asleep (Sleep initiation)?
> - Staying asleep? (Sleep maintenance)?I've taken a small amount of Seroquel specifically for sleep since 2007. I like the Lupin generic (even more than the brand) - it seems really good at putting me to sleep like clockwork an hour after taking it. I don't have any issues w/ waking during the night nor hangovers at 12.5-25mg. I think it helped a bit w/ anxiety/depression when I would take it at 50mg-100mg, but due to the potential for weight gain, and not wanting to deal w/ w/d if I ever wanted to come off, I tapered years ago and try to keep it at 25mg max.
> 2. Maintained efficacy over months or years?Yea, I've never built any tolerance to it. One of the generics (Accord I think) didn't work well at the same dose, but I have a stockpile of Lupin from being prescribed 100mg for years and only taking 1/4. Lupin works best for me for sleep.
> 3. What dosage?
12.5 to 25mg. 12.5mg is -enough- but at the moment I'm back at 25mg in the hope that it helps a little bit w/ anxiety (specifically from methylphenidate)
> 4. The mechanism most responsible for Seroquel inducing sleep?
AFAIK it acts strongly on histamine at low doses.
> .
>
> Thanks much for any help people can offer.
>
>
> - Scott
>
>I highly recommend it if you need help getting to sleep. I haven't had any issues at 25mg. No weight gain I've ever noticed - and no tolerance a decade+ later.
Posted by undopaminergic on July 9, 2022, at 8:42:56
In reply to Re: Quetiapine / Seroquel for sleep?, posted by PeterMartin on July 8, 2022, at 18:22:06
>
> > 4. The mechanism most responsible for Seroquel inducing sleep?
>
> AFAIK it acts strongly on histamine at low doses.
>I've read that serotonin 5-HT2A antagonism may be beneficial for sleep *quality*. That was in relation to cyproheptadine (Periactin), which is a first-generation (sedating) anti-histamine.
-undopaminergic
Posted by rjlockhart37 on July 10, 2022, at 22:17:45
In reply to Quetiapine / Seroquel for sleep?, posted by SLS on July 7, 2022, at 7:20:44
seroquel used to knock me out, they started lower doses with me, then we finally got to 600mg at night. It knocked me out compete, but also rerember if i wasnt sleeping i was 'serozoned' walking around everything seemed 'sero' or 'quelled' just like it's name. It lasts about 6 hours. Some people take it for bipolar depression, but me i could not stand seroquel, i was in another reality being on it at 600mg
Posted by Lamdage22 on July 20, 2022, at 13:53:33
In reply to Quetiapine / Seroquel for sleep?, posted by SLS on July 7, 2022, at 7:20:44
> Can anyone describe their personal experience using quetiapine (Seroquel) as a hypnotic (sleep-aid)?
>
> 1. Quality of sleep
> - Falling asleep (Sleep initiation)?
> - Staying asleep? (Sleep maintenance)?Both pretty good for a less addictive compound.
> 2. Maintained efficacy over months or years?
Somewhat reduced, dosage needed tends to increase. I have hardcore psychosocial stressors though.
> 3. What dosage?
450 at night and 200 extended release in the morning.
> 4. The mechanism most responsible for Seroquel inducing sleep?
I have no clue.
Posted by undopaminergic on July 23, 2022, at 1:48:24
In reply to Re: Quetiapine / Seroquel for sleep?, posted by Lamdage22 on July 20, 2022, at 13:53:33
>
> > 4. The mechanism most responsible for Seroquel inducing sleep?
>
> I have no clue.
>Histamine H1-receptor antagonism, with some possible contribution of serotonin 5-HT2A receptor antagonism.
-undopaminergic
Posted by SLS on July 23, 2022, at 8:38:46
In reply to Re: Quetiapine / Seroquel for sleep?, posted by undopaminergic on July 23, 2022, at 1:48:24
Hi, UD.
> >
> > > 4. The mechanism most responsible for Seroquel inducing sleep?
> >
> > I have no clue.
> Histamine H1-receptor antagonism, with some possible contribution of serotonin 5-HT2A receptor antagonism.
That makes sense. The histamine blocker, Benadryl, makes me feel like crap. Is there a possibility that Seroquel would too?Thanks.
- Scott
Posted by undopaminergic on July 23, 2022, at 11:09:55
In reply to Re: Quetiapine / Seroquel for sleep? » undopaminergic, posted by SLS on July 23, 2022, at 8:38:46
> Hi, UD.
Hi SLS.
> > >
> > > > 4. The mechanism most responsible for Seroquel inducing sleep?
> > >
> > > I have no clue.
>
>
> > Histamine H1-receptor antagonism, with some possible contribution of serotonin 5-HT2A receptor antagonism.
>
>
> That makes sense. The histamine blocker, Benadryl, makes me feel like crap. Is there a possibility that Seroquel would too?
>It's always possible. However, as far as I know, Seroquel is the only antipsychotic drug that has been associated with drug-seeking behaviour, which suggests to me that some people actually enjoy it.
-undopaminergic
Posted by Lamdage22 on July 23, 2022, at 12:56:25
In reply to Re: Quetiapine / Seroquel for sleep?, posted by undopaminergic on July 23, 2022, at 11:09:55
> It's always possible. However, as far as I know, Seroquel is the only antipsychotic drug that has been associated with drug-seeking behaviour, which suggests to me that some people actually enjoy it.
I dont get that. I find Zyprexa more ejoyable. Every time it was introduced it gave me an incredible sense of pacification.
Posted by SLS on July 24, 2022, at 9:16:36
In reply to Re: Quetiapine / Seroquel for sleep?, posted by Lamdage22 on July 23, 2022, at 12:56:25
Hi.
> > It's always possible. However, as far as I know, Seroquel is the only antipsychotic drug that has been associated with drug-seeking behaviour, which suggests to me that some people actually enjoy it.
That's interesting. If you have ever taken Benadryl, how would you compare the mental states produced by Benadryl versus Seroquel?
I am not unique in having a dysporic reaction to Benadryl. Seroquel sounds like an ideal sleep aid.
> I dont get that. I find Zyprexa more ejoyable. Every time it was introduced it gave me an incredible sense of pacification.The first time I took olanzapine (Zyprexa), it was used to cap a manic reaction to Nardil. The day after my first evening dose, I felt great. The improvement was shot-lived, though, and lasted for no longer than a week. Two weeks ago, I tried Zyprexa for sleep. It made me feel like crap the next day. Until I speak to my doctor next, I might try to open a 5mg capsule and take a fraction of its contents.
Interestingly, when Zyprexa first came out, there were numerous reports of it causing mania. I don't know what became of these reports, and why they never emphasized?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161651/
- Scott
Posted by SLS on July 24, 2022, at 9:17:31
In reply to Re: Quetiapine / Seroquel for sleep? » Lamdage22, posted by SLS on July 24, 2022, at 9:16:36
Google search:
https://www.google.com/search?&q=Olanzapine-induced+mania
- Scott
Posted by TriedEveryMedication on July 26, 2022, at 12:11:18
In reply to Quetiapine / Seroquel for sleep?, posted by SLS on July 7, 2022, at 7:20:44
Not taking Seroquel, but I am taking Asenapine for sleep.
2.5mg. I don't usually need help falling asleep, but this keeps me asleep for about 7 hours. Otherwise I'd probably wake up at 2am and not be able to go back to sleep for a couple hours.
side-effects are minimal, but I do feel weirdly restless once in a while during the day
This is the end of the thread.
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