Posted by PeterMartin on July 8, 2022, at 18:22:06
In reply to Quetiapine / Seroquel for sleep?, posted by SLS on July 7, 2022, at 7:20:44
> Can anyone describe their personal experience using quetiapine (Seroquel) as a hypnotic (sleep-aid)?
>
> 1. Quality of sleep
> - Falling asleep (Sleep initiation)?
> - Staying asleep? (Sleep maintenance)?I've taken a small amount of Seroquel specifically for sleep since 2007. I like the Lupin generic (even more than the brand) - it seems really good at putting me to sleep like clockwork an hour after taking it. I don't have any issues w/ waking during the night nor hangovers at 12.5-25mg. I think it helped a bit w/ anxiety/depression when I would take it at 50mg-100mg, but due to the potential for weight gain, and not wanting to deal w/ w/d if I ever wanted to come off, I tapered years ago and try to keep it at 25mg max.
> 2. Maintained efficacy over months or years?Yea, I've never built any tolerance to it. One of the generics (Accord I think) didn't work well at the same dose, but I have a stockpile of Lupin from being prescribed 100mg for years and only taking 1/4. Lupin works best for me for sleep.
> 3. What dosage?
12.5 to 25mg. 12.5mg is -enough- but at the moment I'm back at 25mg in the hope that it helps a little bit w/ anxiety (specifically from methylphenidate)
> 4. The mechanism most responsible for Seroquel inducing sleep?
AFAIK it acts strongly on histamine at low doses.
> .
>
> Thanks much for any help people can offer.
>
>
> - Scott
>
>I highly recommend it if you need help getting to sleep. I haven't had any issues at 25mg. No weight gain I've ever noticed - and no tolerance a decade+ later.
poster:PeterMartin
thread:1120022
URL: http://www.dr-bob.org/babble/20220530/msgs/1120038.html