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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by TriedEveryMedication on July 15, 2018, at 12:13:37
Only been on this med for 4 days but holy hell. I guess that's norepi for you.
My depression has gone from a 4/10 (while on prozac+despiramine) to an 11/10.
Looks like it can't be combined with an ssri, either. (or can it?)
does this get better?
(I had to quit the desipramine + prozac because my resting heart rate was 129 :/ )
Posted by Christ_empowered on July 15, 2018, at 15:00:14
In reply to Fetzima, the pit of despair, posted by TriedEveryMedication on July 15, 2018, at 12:13:37
hi. when you say you deal with 'depression' what do you mean? agitation, lethargic, too little sleep, too much sleep???
maybe antidepressants aren't for you. old school remedies...valium+stimulant, neuroleptic+stimulant, neuroleptic+benzodiazepine, etc....are perfectly viable options for some people, if drugs are the way to go.
have talking treatments ever helped? im not so sure why some people are so gung ho about therapy...to me, its conversation, and it can go very wrong, too...but it does help a lot of people.
"alternative" stuff...I don't know that much about. I take high dose vitamins (Orthomolecular) on top of 2 standard pscyh drugs. It works well for me, but its more of a booser than a stand alone thing...other people swear by herbs, amino acids, detoxes, etc.
wish i could be of more help, but...newer psych drugs are less toxic and such than the older ones, but its pretty much the same stuff (block dopamine, boost dopamine, blah blah blah), just repackaged and cleaned up a bit.
hope this helps a bit.
Posted by beckett2 on July 17, 2018, at 9:06:23
In reply to Fetzima, the pit of despair, posted by TriedEveryMedication on July 15, 2018, at 12:13:37
I had a poor reaction to Savella including physical symptoms (increased preexisting and new pain), which is paradoxical given it's use in fibromyalgia. I lasted about a week. Have you spoken to your doctor?
Posted by TriedEveryMedication on July 18, 2018, at 15:26:28
In reply to Fetzima, the pit of despair, posted by TriedEveryMedication on July 15, 2018, at 12:13:37
I feel agitated on fetzima + coffee.
been drinking decaf today and things are worlds better
Posted by bleauberry on July 19, 2018, at 8:57:16
In reply to Fetzima, the pit of despair, posted by TriedEveryMedication on July 15, 2018, at 12:13:37
Well, I'm not trying to sound like a wise guy, and no insult intended at all, but I did sort of want to make a point. So apologies in advance if this is in anyway abrasive. That is, that if you haven't tried treating your depression with an integrative-oriented LLMD, or with antibiotics, then you have not even come anywhere close to having tried every medication. The best cures that my eyes have seen in the world of psychiatry came from non-psychiatric prescriptions. That's all I wanted to say.
Have you ever tried Milnacipran? Prozac+Zyprexa+Modafinil? Prozac+Zyprexa+Ritalin? Just based on your posts and things you talk about, I would guess these combinations might have better potential for you than TCAs.
Posted by TriedEveryMedication on July 19, 2018, at 9:38:04
In reply to Re: Fetzima, the pit of despair, posted by bleauberry on July 19, 2018, at 8:57:16
> Well, I'm not trying to sound like a wise guy, and no insult intended at all, but I did sort of want to make a point. So apologies in advance if this is in anyway abrasive. That is, that if you haven't tried treating your depression with an integrative-oriented LLMD, or with antibiotics, then you have not even come anywhere close to having tried every medication. The best cures that my eyes have seen in the world of psychiatry came from non-psychiatric prescriptions. That's all I wanted to say.
>
> Have you ever tried Milnacipran? Prozac+Zyprexa+Modafinil? Prozac+Zyprexa+Ritalin? Just based on your posts and things you talk about, I would guess these combinations might have better potential for you than TCAs.
>
>In fact I have tried Milnacipran. And various antibiotics, minocyclin, doxycyclin, ciproflacin, flagyl. And d-cycloserine. zyprexa etc. are a no-go because I'm an engineer and I can't think on those meds and I just lay in bed all day. prozac + ritalin = extreme sedation. prozac + modafinal = extreme sedation.
Really, I have tried nearly class of medication even remotely relevant to depression. Including biologic an anti-TNF drug. And then many combinations.
the thing that comes closest to working is prozac + desipramine. The cardiac side-effects don't allow me to stay on it long.
Posted by ed_uk2010 on July 21, 2018, at 15:42:51
In reply to Re: Fetzima, the pit of despair » bleauberry, posted by TriedEveryMedication on July 19, 2018, at 9:38:04
>the thing that comes closest to working is prozac + desipramine. The cardiac side-effects don't allow me to stay on it long.
Due to tachycardia? Tried a beta blocker? Atenolol for example.
Posted by TriedEveryMedication on July 21, 2018, at 16:18:46
In reply to Re: Fetzima, the pit of despair » TriedEveryMedication, posted by ed_uk2010 on July 21, 2018, at 15:42:51
> >the thing that comes closest to working is prozac + desipramine. The cardiac side-effects don't allow me to stay on it long.
>
> Due to tachycardia? Tried a beta blocker? Atenolol for example.
>I'll bounce this off my doc. Thanks.
Posted by SLS on July 21, 2018, at 16:44:47
In reply to Re: Fetzima, the pit of despair » ed_uk2010, posted by TriedEveryMedication on July 21, 2018, at 16:18:46
> > >the thing that comes closest to working is prozac + desipramine. The cardiac side-effects don't allow me to stay on it long.
> >
> > Due to tachycardia? Tried a beta blocker? Atenolol for example.
> >
>
> I'll bounce this off my doc. Thanks.Maybe nortriptyline instead of desipramine?
- Scott
Posted by ed_uk2010 on July 22, 2018, at 5:27:06
In reply to Re: Fetzima, the pit of despair » ed_uk2010, posted by TriedEveryMedication on July 21, 2018, at 16:18:46
> > >the thing that comes closest to working is prozac + desipramine. The cardiac side-effects don't allow me to stay on it long.
> >
> > Due to tachycardia? Tried a beta blocker? Atenolol for example.
> >
>
> I'll bounce this off my doc. Thanks.That would be good. Atenolol (eg. initially 25mg/day) is potentially suitable due to minimal penetration into the brain, lower effects than most beta blockers on non-cardiac sites, and minimal drug interactions.
Posted by TriedEveryMedication on July 22, 2018, at 9:01:51
In reply to Re: Fetzima, the pit of despair » TriedEveryMedication, posted by SLS on July 21, 2018, at 16:44:47
> > > >the thing that comes closest to working is prozac + desipramine. The cardiac side-effects don't allow me to stay on it long.
> > >
> > > Due to tachycardia? Tried a beta blocker? Atenolol for example.
> > >
> >
> > I'll bounce this off my doc. Thanks.
>
> Maybe nortriptyline instead of desipramine?
>
>
> - Scottnortrip never did anything for my add by itself. I suppose in combo with prozac it might be different. No problems combining nortrip with prozac?
do you think levomilnacipran can be combined with fluoxetine at lowish dosages?
Posted by ed_uk2010 on July 22, 2018, at 11:08:23
In reply to Fetzima, the pit of despair, posted by TriedEveryMedication on July 15, 2018, at 12:13:37
>I had to quit the desipramine + prozac because my resting heart rate was 129 :/ )
So, how well did this combination work (or not work)? Did you have any adverse effects apart from increased heart rate?
Sinus tachycardia at rest is extremely typical of desipramine. And with fluoxetine, you'd want to stick to very low doses of desipramine due to the metabolic interaction.
If an ECG/EKG showed that it was just the typical sinus tachycardia and nothing more serious, you could consider an add on, since sinus tachy isn't particularly difficult to treat.
First though, it would be worthwhile reducing the dose of desipramine and finding out whether you can maintain a response at a lower dose without tachycardia. The dose may be very low, because fluoxetine interacts - it's not like taking desipramine alone.
Posted by SLS on July 22, 2018, at 11:20:17
In reply to Re: Fetzima, the pit of despair, posted by TriedEveryMedication on July 22, 2018, at 9:01:51
Desipramine would be better for ADD.
Ed offers accurate information and wise suggestions.
- Scott
This is the end of the thread.
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