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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Jeroen on January 3, 2014, at 23:27:19
magic bullet found -> minocycline
I THINK.... : D
i should have kept taking it at lower dose, damn this forced psychiatry anxiety works on my nerves
the startup side effects werent a laugh either still.... i feel much better (for how long it will last)
bleauberry told me about the honeymoon days...
Posted by SLS on January 4, 2014, at 4:57:21
In reply to magic bullet found -) minocycline, posted by Jeroen on January 3, 2014, at 23:27:19
> magic bullet found -> minocycline
>
> I THINK.... : D
>
> i should have kept taking it at lower dose, damn this forced psychiatry anxiety works on my nerves
>
> the startup side effects werent a laugh either still.... i feel much better (for how long it will last)What were the startup side effects?
Please post at least twice a day. I would like to see you get more support during these first few weeks of taking minocycline. You might need the reassurance. You are not always a patient patient. :-) Neither am I, for that matter.
You might have to get up to 200 mg/day of minocyclne to get the most consistent benefit. I can't predict for you how quickly you will be able to get there. Maybe 100 mg/day will be enough, but I doubt you can maintain a therapeutic response at a dosage any lower than that. Meanwhile, you are doing the right thing for yourself - start low and go slow. I didn't begin taking 200 mg/day until week 3. I could probably have gotten there in a week, but why take the chance of becoming prematurely discouraged by a startup side effect? You might quit for the wrong reasons. Go slow.
DO NOT GIVE UP ON THIS DRUG!
- Scott
--------------------------------------------http://clinicaltrials.gov/show/NCT01809158
1. An open label study of 22 patients with treatment-resistant schizophrenia, using minocycline 150 mg/d for four weeks, reported an improvement in both positive and negative symptoms.
2. Two double blind trials have been carried out. In one study, 73 patients with schizophrenia of less than five years' duration were randomized to minocycline 200 mg or placebo for 12 months: "all symptom measures improved significantly" especially in the negative symptoms. In the other study, 54 "early phase" (symptoms of less than five years) patients were randomized to minocycline 200 mg/d or placebo for six months; the authors reported a significant improvement in negative symptoms measured using Scale for the Assessment of Negative Symptoms (SANS) and Clinical Global Impressions scale (CGI) and a significant improvement in some test of executive function.
-------------------------------------------
http://clinicaltrials.gov/show/NCT01433055
Minocycline Dosing:
Minocycline (Dynacin® or generic) will be available in 50, 75 and 100 mg capsules. There will be matched placebo-minocycline capsules for each minocycline capsule strength. During the first week subjects will receive one 50 mg capsule twice per day (minocycline 100 mg total or matching placebo) and during weeks 2-10 subjects will receive 2- 50 mg capsules twice per day If a subject should complain of any side effect, then the blind psychiatrist will be allowed to omit the next dose of study medication and then continue the subject on the optimal treatment dose. If, despite this intervention, the subject is still unable to tolerate the 200 mg/day dose, then the dose may be lowered to 150 mg to alleviate side effects and minimize attrition.
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Posted by Jeroen on January 4, 2014, at 5:22:38
In reply to Re: magic bullet found -) minocycline » Jeroen, posted by SLS on January 4, 2014, at 4:57:21
I have quit it a day and half ago, i shoudnt have done it, my situation requires a lawyer
anyway i am having relief of depression and psychosis after this short trial... i want to get back on asap on a low dose under superviewing of my old psychiatrist..
I need a lawyer but i don't have the money, this is gonne be a problem, im stuck again
the startup side effects were hars thats why i quit, but no adverse effects yet when i took it, i was overstimulated, tired, depressed, but now i am the opposite,
i need a lawyer (crying)
Posted by Jeroen on January 4, 2014, at 5:23:48
In reply to To SLS, posted by Jeroen on January 4, 2014, at 5:22:38
please advice about my next move please im stuck
Posted by SLS on January 4, 2014, at 6:13:57
In reply to please advice about my next move please im stuck, posted by Jeroen on January 4, 2014, at 5:23:48
> please advice about my next move please im stuck
Unfortunately, the only thing I can think of is for you to present your doctors with information that they obviously don't have.
I'll see what I can do. In the meantime, I gave you 2 articles for your doctors to read.
- Scott
Posted by SLS on January 4, 2014, at 7:21:23
In reply to please advice about my next move please im stuck, posted by Jeroen on January 4, 2014, at 5:23:48
> > please advice about my next move please im stuck
>
> Unfortunately, the only thing I can think of is for you to present your doctors with information that they obviously don't have.
>
> I'll see what I can do. In the meantime, I gave you 2 articles for your doctors to read.Try these, Jeroen:
- Scott------------------------------------------------
Google Search: https://www.google.com/#q=minocycline+schizophrenia
http://www.ncbi.nlm.nih.gov/pubmed/19895780
http://www.ncbi.nlm.nih.gov/pubmed/19855900
http://www.ncbi.nlm.nih.gov/pubmed/18991666
http://www.trialsjournal.com/content/14/1/406
-----------------------------------------------------
Minocycline:
1. Is neuroprotective.
2. Reduces brain inflammation
3. Reduces the number of glutamate receptors.
4. Demonstrates antidepressant and antipsychotic properties in mouse models.
5. Is reported to act synergistically with noradrenergic antidepressants to treat depression - desipramine (but not fluoxetine).
6. Is reported to act synergistically with NMDA antagonists.
7. Reduces glutamate excitotoxicity by reducing the formation of quinolic acid, a NMDA agonist.
8. Reduces mitochondrial release of cytochrome C.
9. Modulates several signaling pathways.
10. Reduces microglial activation.
11. Has been reported anecdotally to successively treat depression.
12. Reduces the expression of lipopolysaccharide-induced pro-inflammation cytokines, an effect that acts as an antidepressant in animal models.
13. Increases neurite growth in response to nerve growth factor (NGF).
14. Inhibits high levels of PKC and GSK-3 alpha;
15. Decreases nitric oxide synthetase, thereby reducing free radicals which damage neurons and glia.
16. Reduces glutamate release.----------------------------------------------------
Posted by Jeroen on January 4, 2014, at 7:56:51
In reply to Re: please advice about my next move please im stuck » Jeroen, posted by SLS on January 4, 2014, at 7:21:23
he wont ever read these
Posted by Phillipa on January 4, 2014, at 9:16:44
In reply to Re: please advice about my next move please im stuck » Jeroen, posted by SLS on January 4, 2014, at 7:21:23
Scott I don't think Jeroen will mind if I explain a bit further his situation. Ed UK knows the full situation. If you have contact with him you might write him. Jeroen was home on a vacation and saw old pdoc who did prescribe mino for him. Unfortunately he is now back at the clinic with a different pdoc who will not allow him to take mino. Maybe you can babblemail him? PJ
Posted by Emme_V2 on January 4, 2014, at 13:04:54
In reply to my current pdoc is oldfashioned, posted by Jeroen on January 4, 2014, at 7:56:51
> he wont ever read these
Have you asked him to speak with the other doctor who did prescribe the minocycline? Or ask the doctor who prescribed the mino to contact the doctor at the clinic? Perhaps the one who prescribed the mino can advocate on your behalf.
Posted by bleauberry on January 6, 2014, at 12:25:03
In reply to magic bullet found -) minocycline, posted by Jeroen on January 3, 2014, at 23:27:19
I have been following your posts Jereon. I have been looking for things that would rule in or rule out my own suspicions, which you have known all along for years.
What I have seen recently is a picture perfect classic textbook case of what happens when someone infected with lyme or lyme-like first starts an appropriate antibiotic. I told you about that in our babblemails. I definitely saw some Herxheimer stuff in your posts....the lethargy, akathisia, depression....so hard to believe, but those are NOT psychiatric. Those are toxins of bugs doing that!
And your honeymoon period is obvious.
I mentioned it in another post and I would like to say it again if I can. That is, think in terms of months not days. Yeah, I know, been there done that, every hour seems to be a torture, so how can we NOT think in terms of days, right? Well, what I mean is, we have to do all we can through every day to try to make the best of it, but in terms of counting time periods to celebrate, with antibiotics the time period needs to be monthly, not daily.
Posted by Jeroen on January 6, 2014, at 13:34:37
In reply to Re: magic bullet found -) minocycline, posted by bleauberry on January 6, 2014, at 12:25:03
thanks bleauberry i could also not have done it witouth you and the pdoc who suggested it
This is the end of the thread.
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Dr. Bob is Robert Hsiung, MD,
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