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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by ParnateStarted2008 on June 1, 2009, at 18:57:11
Hi fellow Babbler's,
I take 100mg Parnate/day for chronic Social Phobia, Agoraphobia with Panick attacks.
Within a half hour of dosing time I begin to sweat REALLY bad. I can soak a bed or it seems like I am melting. I dont feel hot or bad, just sweating and slight body numb that can put me down for a hour nap.
Also my heart ramps up to about 100 - 110 bps. This all lasts for about 1.5 - 2 hours then Im back to normal.
It doesn't matter how I plit my dosage ie. 10mg taken ten times a day or 50mg taken twice a day.
Other then that I can tolerate Parnate very well. Im hoping to find an augment that works well for me soon because its just not doing a good enough job. Parnate is better then anything else Ive been on (side effect wise) which is all the common SSRI's and Nardil, sometimes with or without Lithium or Lamictal( I always give a new trial long enough to work ). Im at a baseline now of just Parnate. Benzo's work good enough to have a life when in combo with Parnate but my tolerence is so high to benzo's I dont want to take them daily, eg 4 mg clonazepam is the minimum to get me out of the house and interact ok socially, I bet after a week or 2 id be at 6mg/day. And I dont have a history of longterm benzo use or abuse, I just need to much of them for it to be a good combo.. but Im still considering it.Thanks if anyone has input about the sweating or heart beat issue.
Posted by shasling on June 1, 2009, at 19:26:06
In reply to Parnate, sweating + fast heart beat?, posted by ParnateStarted2008 on June 1, 2009, at 18:57:11
From my experieance with parnate prefuse sweating where u wipe ur forehead and beads of sweat reappear again means its ineteracting with something.
Either that or its simply to high for ur body,in my case when this happens the best thing for me is a benzo and sleep,luckly and I DONT NOT SAY THIS AS FACT but this sweating indicates a minor interaction,....unless accompainied by a major heacache ,red spotting,nauseau etc then usualy for me its just parnate is playing nice with another med,or i just am taking to much.
Example i take 50 mg tops,when i took 70 once this sweating happened to me,after benzo and napping i was ok.
With the high benzo worry,u can try taking the benzos PRIOR to parnate,giving time to let the benzos work then taking parnate,however if it continues i would not advocate you just keep on,who knows what damage your doing.
I can offer a million suggestions but im sure u thought of them already,i will say this,i had a real parnate interaction,and its nothing you want,you realise once it happens u cant turn back the clock,i was iced down,given activated charcoal and had to beg the doc to google maois before they injected me with meds,luckly she did and i was iv ed only water.
But i promise u a headache was a pleasure,my head hurt so bad i swore i was gonna hemorage,luckly with lots of intense pain i awoke to a toxiclogist who actualy know about maois,after a stiff talk from him,my brother over heard him on the phone saying patient came very close to hemorage and death.
Please becareful remember u cant turn back if it happens,and youll wish to god u can.
Posted by ParnateStarted2008 on June 1, 2009, at 19:53:45
In reply to Re: Parnate, sweating + fast heart beat?, posted by shasling on June 1, 2009, at 19:26:06
Thanks shasling,
Yes it is the type of sweat that just keeps beading down my forehead and body.
I recently(days ago) got off lamictal and the sweating and fast heartbeat stopped. I was so happy. Now its back unfortunately. At the moment I take ZERO other psych drugs or anything for that matter except 3-4mg Clonazepam as needed. I will try to take my CLonazepam 2hrs prior to a PArnate dose and see what happens.
I take my blood pressure regularly (got my own pump) and I am fine, just elevated heart beat. The body numbing feels nice like the Parnate is metabolizing into an odd opiate (maybe thats the amphetamine thing) and makes me a bit weak and tired which gives me a comfortable nap while I sweat with a pounding heart.
Ive always watched watched my BP monitor, with food too. It must just be reacting to "me" (visa versa).
MAybe dropping down the dosage when I find something to augment it will help. I agree this could very well be causing damage. Jezz MAybe Upping the dosage will help. This is The only AD so far with so little Side effects(even these SE's are more tolerable then other drugs ive been on). Feels its almost working just need a little more boost from something.
Posted by shasling on June 1, 2009, at 20:46:06
In reply to Re: Parnate, sweating + fast heart beat?, posted by ParnateStarted2008 on June 1, 2009, at 19:53:45
yess a parnate induced nap is the BOMB,just be careful.
Posted by Phillipa on June 1, 2009, at 23:25:20
In reply to Re: Parnate, sweating + fast heart beat?, posted by ParnateStarted2008 on June 1, 2009, at 19:53:45
Parnate please be careful I know Shasling knows Parnate. Seriously Love Phillipa
Posted by ParnateStarted2008 on June 2, 2009, at 14:37:23
In reply to Re: Parnate, sweating + fast heart beat?, posted by shasling on June 1, 2009, at 20:46:06
> yess a parnate induced nap is the BOMB,just be careful.
Do you know why Parnate can induce such a weird "BOMB" nap?? It feels like some opiate triggered nap.. kindof numbs the body. Its not something I would say is a good side effect, as the feeling doesn't help with anything else (anxiety, motivation or interest).
Posted by shasling on June 2, 2009, at 16:28:25
In reply to Re: Parnate, sweating + fast heart beat?, posted by ParnateStarted2008 on June 2, 2009, at 14:37:23
> > yess a parnate induced nap is the BOMB,just be careful.
>
> Do you know why Parnate can induce such a weird "BOMB" nap?? It feels like some opiate triggered nap.. kindof numbs the body. Its not something I would say is a good side effect, as the feeling doesn't help with anything else (anxiety, motivation or interest).
>
>
>there is less then ZERO SCIEANCE behind this,but dopamine is also inhibtory as well as stimulative.
Unlike bedtime sleep which is usualy gaba induced,where u groggly fall alseep as well as wake up,with the parnate nap,in my case anyway i fall asleep with a groggy affect,its odd as u know already,and i also wake feeling good not groggy.
Again this is just what im thinking,i just know gaba agents such as ambien,benzos,etc make me depressed as they put me to sleep,parnate naps i feel nice and serine as i fall asleep like i actualy enjoy just laying there whether i sleep or not.
Unfortantly as i stated parnate was made by a sole chemisct and sold to glaxco,so glaxco has almost nill techniacl info on this drug,if you wanna hear them babble their words call them,ask to speak to a chem tech there,and they will offer nothing more info wise then the data sheets have,the company sent me a packet after my call to write down what i felt on parnate and send back,yeah right up theirs lol
Posted by linkadge on June 7, 2009, at 20:00:24
In reply to Re: Parnate, sweating + fast heart beat?, posted by shasling on June 2, 2009, at 16:28:25
Most MAOIs royally mess with sleep patterns. Most people who take them simply cannot fall asleep during the night and end up with overpowering sleep attacks during the day.
Then you start to develop strange paranoid like behaviors as you are deprived on a long term basis of certain critical stages of REM sleep.
They kill anhedonia about the same time you start to get paranoid. Then you are not worried about life being meaningless as you are concerned about people being after you, or start preparing for the pending neuclear war.
Well....I suppose not everybody has the same responce to parnate as I.
Linkadge
Posted by ParnateStarted2008 on June 7, 2009, at 20:27:49
In reply to Re: Parnate, sweating + fast heart beat?, posted by linkadge on June 7, 2009, at 20:00:24
> Most MAOIs royally mess with sleep patterns. Most people who take them simply cannot fall asleep during the night and end up with overpowering sleep attacks during the day.
>
> Then you start to develop strange paranoid like behaviors as you are deprived on a long term basis of certain critical stages of REM sleep.
>
> They kill anhedonia about the same time you start to get paranoid. Then you are not worried about life being meaningless as you are concerned about people being after you, or start preparing for the pending neuclear war.
>
> Well....I suppose not everybody has the same responce to parnate as I.
>
> Linkadge
>
>Intresting indeed. Im definitely lacking any kind of deep sleep. Weird things do happen. and then worrying from being deprived from sleep gives me night paranoia, so keeps me awake too..
The sweating seems to have decreased alot* from dosing away from meal time.
Still I see potential for Parnate soon
Posted by ColoradoSnowflake on June 7, 2009, at 22:49:50
In reply to Re: Parnate, sweating + fast heart beat?, posted by ParnateStarted2008 on June 7, 2009, at 20:27:49
Dear "ParnateStarted2008
"Still I see potential for Parnate soon"
How long have you been on Parnate? Are you still waiting for it to "kick in"?
I've been on it for 5 weeks now (40mg) and I'm getting impatient! It doesn't make me sweat. But I want to feel GOOD, not just tired!How do you feel? (Well,I hope!)
Gayle
Posted by desolationrower on June 8, 2009, at 5:24:14
In reply to Re: Parnate, sweating + fast heart beat? » ParnateStarted2008, posted by ColoradoSnowflake on June 7, 2009, at 22:49:50
REM is like the opposite of deep sleep.
-d/r
Posted by ParnateStarted2008 on June 8, 2009, at 17:39:54
In reply to Re: Parnate, sweating + fast heart beat? » ParnateStarted2008, posted by ColoradoSnowflake on June 7, 2009, at 22:49:50
> Dear "ParnateStarted2008
>
> "Still I see potential for Parnate soon"
>
> How long have you been on Parnate? Are you still waiting for it to "kick in"?
> I've been on it for 5 weeks now (40mg) and I'm getting impatient! It doesn't make me sweat. But I want to feel GOOD, not just tired!
>
> How do you feel? (Well,I hope!)
> Gayle
>Hi Gayle,
Parnate HAS kicked in. I started at 40mg/day, then 50, 60, 70, 80, now 100mg/day. I waited at each dose increase 4-6 weeks to wait and feel the full responce of each increment increase. As for most the first 2-3 days of each dose increase gave increadable remission on my anxiety, then would leave.
After my first couple weeks at 50 the antidepressant effect felt very good and still does at 100mg. Im not using it for depression but as a last resort for social Phobia. it has given me wonderful days but is never constant for the anxiety. im looking for the right augmentor or high dose. (ive tried quite a few already with not much success)
At 60 mg my emotions have been overstimulated (in a good way). The antidepressant effect has never left or pooped out. Motivation and all the human emotions one 'should' feel when not depressed I have an abundance of (joy, love, anger, sadness, surprise, fear). I know I am making this sound wonderful but remember Im not taking this for depression so maybe that is why I feel the AD effect so strongly. It took me a month or 2 to be able to control and handel the profound emotions I now feel. I could just cry all the time from happy moments or the love I have for a song or person. Sounds amazing hey! well not so much for me as I already had enough of the other feelings, I need more Anxiolytic effect big time. Im seeing my new pdoc on thursday to see what we can do for augmentation or something for the anxiety. Parnate has not made the anxiety worse.
I have been on it now for 10 months.
I havent give up on it yet because it has given me the least amount of bad side effects then anything else Ive tried. Once in a while something makes the anxiolytic effect kick in, and its this glimmer of hope that keeps me with it.
Hope this helps.
ummm.. off topic but ya my Phobia has kept me in my room for the last 2 days so it really sucks but I can enjoy movies...
Posted by ParnateStarted2008 on June 8, 2009, at 17:47:00
In reply to Re: Parnate, sweating + fast heart beat?, posted by desolationrower on June 8, 2009, at 5:24:14
> REM is like the opposite of deep sleep.
>
> -d/rHa, ya I messed up there.. Im missing a Heck of alot of sleep in all phases.. 12mg seroquel gets me a good sleep but then I have a complete lack of motivation the next day and am soo tired. I keep some on hand but try to never take it cuz Id rather feel ok after no sleep then horrible after a good sleep.
Posted by ColoradoSnowflake on June 9, 2009, at 15:02:17
In reply to Re: Parnate, sweating + fast heart beat?, posted by ParnateStarted2008 on June 8, 2009, at 17:39:54
Hi! Thanks for all the great info! It's very meaningful to hear about your personal reactions. How wonderful Parnate is making you feel so very good!!! At this point I just want to not be depressed or exhausted. I've only been on Parnate for 6 weeks so I guess I shouldn't expect so much, but the fatigue is killing me. I'm trying to change my sleep med to something other than amytriptyline which is so tiring the next day. I tried Ambien 5mg two nights ago and I didn't sleep very much and was very depressed the whole next day. Last night I tried a quarter of an amytriptyline (6 1/4mg) and got some sleep but tired again today. I would like to ask pdoc about raising my Parnate and about Adderall. I tried a LITTLE ritalin last week but it made me anxious and depressed. I sure wish the Parnate would work faster! Gayle
Posted by ParnateStarted2008 on June 9, 2009, at 15:53:37
In reply to Re: Parnate, sweating + fast heart beat? » ParnateStarted2008, posted by ColoradoSnowflake on June 9, 2009, at 15:02:17
> Hi! Thanks for all the great info! It's very meaningful to hear about your personal reactions. How wonderful Parnate is making you feel so very good!!! At this point I just want to not be depressed or exhausted. I've only been on Parnate for 6 weeks so I guess I shouldn't expect so much, but the fatigue is killing me. I'm trying to change my sleep med to something other than amytriptyline which is so tiring the next day. I tried Ambien 5mg two nights ago and I didn't sleep very much and was very depressed the whole next day. Last night I tried a quarter of an amytriptyline (6 1/4mg) and got some sleep but tired again today. I would like to ask pdoc about raising my Parnate and about Adderall. I tried a LITTLE ritalin last week but it made me anxious and depressed. I sure wish the Parnate would work faster! Gayle
>Ya MOAI's can sure make you tired and weak. I was like that for a month when I started Nardil over a year ago. I could barely lift my legs or drive more then 10km before wanting to just pass out and sleep.
it went away tho after a month or so.
I switched overnight from 105mgNardil to 40mgParnate and felt no initial startup fatigue from the Parnate I guess since I was already on a MAOI.
My advice would be to keep raising the dose by 10 mg every 1-4 weeks until something happens. I hope your one of the lucky ones who can tolerate Parnate (except insomnia is always soooo bad).
I quit all my sleep meds because they were very much dampening the effect of Parnate, so im in a bit of a insomnia hell right now. Parnate works much better the next day for me if I dont take certain sleep aids. Right now I take 150mg Diphenhydrinate, 20mg propanolol, 1mg Klonopin, 12mg Melatonin, and Im absolutely not left feeling groggy the next day. Trazodone and seroquel completely made me dull and in a anxious and sleepy bad mood the next day. I bet if I used a TCA for sleep it would also wreck my day and deminish any good the parnate would do for that day..Those are my 2 main problems with parnate.
1. Insomnia
2. Augmenting it with something to get the anxiolytic effect to work (I know it has the potential to work on my anxiety, just need the right combO!)PS. Quite a few people dont get a good benefit until they reach 60mg/day or higher. Parnate can be dosed alot higher then the other MAOI's. The 60mgMAX dose doesn't apply much these days.
This is the end of the thread.
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