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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by bearfan on November 13, 2008, at 3:50:40
Can anyone please share experiences about the effectiveness of Stablon vs SSRIs? For me, the SSRI's like Prozac were effective in reducing symptoms but had libido consequences. Is it possible that Stablon is much better in this regard?
Posted by desolationrower on November 13, 2008, at 8:03:40
In reply to Stablon (Tianeptine) vs. SSRIs, posted by bearfan on November 13, 2008, at 3:50:40
I noticed no side effects when i was on coaxil, i think that is how it came out in studies as well...
as far as antidepressant effect, i did not benefit from sris they made me foggy and less motivation than normal, but some of them stopped the crying...tianeptine helped mostly with making me feel more connected to life and life more interesting again...so they 'felt' quite different. Im not sure if responders to one are responders to the other drug, or if they are two different groups so to speak
-d/r
Posted by Quintal on November 13, 2008, at 11:44:49
In reply to Stablon (Tianeptine) vs. SSRIs, posted by bearfan on November 13, 2008, at 3:50:40
Most studies have found tianeptine is as effective as SSRIs and generally better tolerated. A lot of people seem dissapointed that tianeptine doesn't feel very strong. I tended to feel pretty drugged on SSRIs, but not on tianeptine. There isn't much of a feeling of it doing anything, so I was surprised at how quickly my depression lifted. It took me back to baseline in a few days, but didn't take me beyond it - I don't feel inappropriately happy or calm. As far as sex goes, tianeptine heightens tactile sensation (my skin was completely numb on Paxil) and sometimes libido. There is a report of nymphomania in the literature. As far as I'm concerned tianeptine is the model of an ideal antidepressant and we need more drugs like it.
Here is a review of five studies comparing tianeptine to SSRIs - two on Prozac and Paxil, and one on Zoloft:
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1: Encephale. 2003 Jul-Aug;29(4 Pt 1):322-8.Click here to read Links
[A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression]
[Article in French]Olié JP, Baylé F, Kasper S.
Département Universitaire de Psychiatrie, Hôpital Sainte-Anne, 7, rue Cabanis, 75014 Paris.
A meta-analysis was performed to compare the efficacy of tianeptine and selective serotonin reuptake inhi-bitors (SSRI) in the short-term treatment of depression. Consecutive selection and inclusion processes allowed five stu-dies to be selected: two studies on tianeptine versus fluoxetine, two studies on tianeptine versus paroxetine, and one study on tianeptine versus sertraline. A total of 1 348 patients were included in the five studies; 681 subjects received an SSRI and 667 tianeptine. A strict step-by-step methodology was applied in order to legitimize this meta-analysis and to interpret the results. Considering all the patients or those with a Montgomery-Asberg Depression Rating Scale (MADRS) inclusion score greater or equal than 28, none of the assessed parameters (MADRS total score and responder rate) revealed any significant difference between the two treatment groups. Further analysis based on clinical global impression (CGI) items found no significant difference, except for CGI item 3 (therapeutic index), where a tendency (p=0.06 or 0.07 depending on the methodology) was found in favor of tianeptine. All in all, this study confirmed that tianeptine is at least as effective as SSRI, with a trend for a better acceptability profile in the treatment of depressed patients.
PMID: 14615702 [PubMed - indexed for MEDLINE]
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Q
Posted by KimStereo on November 13, 2008, at 12:11:51
In reply to Re: Stablon (Tianeptine) vs. SSRIs, posted by Quintal on November 13, 2008, at 11:44:49
I took it for 5 days just recently..... With my first dose, I got a huge robust effect that abated all of my anxiety symptoms. I went and hugged my hubby, told him how much I loved him, and that I had found the medicine that would cure me and rid me of the terrible anxiety I have endured for so long..
I woke up the next morning only to have it all return. I took 12.5mg three times per day for the next 5 days only to feel my anxiety get worse.
Talk about a big letdown. I had to stop as I could feel my anxiety just getting worse with each dose.
Very strange to have had that chemical response with the first dose.
I stayed up until 3am the first night I was feeling so good, not high or euphoric, just relief and a sense of energy.
In the end, I had a few good hours with my hubby and kids. My husband has some confidence now that the "me" is still there underneath all of the free floating anxiety I experience daily.
Hope that helps.......
Posted by Valero on November 13, 2008, at 15:33:02
In reply to Stablon (Tianeptine) vs. SSRIs, posted by bearfan on November 13, 2008, at 3:50:40
Stablon is an interesting molecule, used acutely at recommended dosages, it can certainly reduce some symptoms of depression, yet it leaves a subjective feeling that "something is missing". Moreover taken over time, apathy can set in, though interestingly enough on discontinuation a "rebound more tangible AD effect can be experienced for a few days. Recently I ran an experiment whereby the 3x12.5mg dose per day was divided into every two hour doses of 3-4mg ( splitting the tabs in 4 , can be done using a blunt paper cutter) There was less of a see-saw effect and little to no sleep anomalies.
It combines nicely with Benzo's, but the latter is so dependence inducing , it's best avoided , except for those in desperate need.
Posted by kenny7 on November 14, 2008, at 16:26:59
In reply to Stablon (Tianeptine) vs. SSRIs, posted by bearfan on November 13, 2008, at 3:50:40
Winner!:Not the SSRI!
Posted by bearfan on November 14, 2008, at 16:34:02
In reply to Re: Stablon (Tianeptine) vs. SSRIs, posted by kenny7 on November 14, 2008, at 16:26:59
Is this just a default response, or do you have personal experience?
Posted by Tomatheus on November 15, 2008, at 3:19:13
In reply to Stablon (Tianeptine) vs. SSRIs, posted by bearfan on November 13, 2008, at 3:50:40
bearfan,
For me, the SSRIs either induced temporary rapid cycling or made my depressive symptoms worse. I'm currently taking tianeptine, and I've found it to be a lot more consistent in its effects than the SSRIs. My mood and energy levels do seem to be elevated in comparison to how I was feeling before I started taking tianeptine, but I still experience all of my depressive symptoms on the tianeptine.
Tomatheus
Posted by West on November 16, 2008, at 17:30:35
In reply to Re: Stablon (Tianeptine) vs. SSRIs » bearfan, posted by Tomatheus on November 15, 2008, at 3:19:13
STABLON
Posted by West on December 21, 2008, at 7:12:18
In reply to Re: Stablon (Tianeptine) vs. SSRIs, posted by Quintal on November 13, 2008, at 11:44:49
I recently finished a month on stablon so i will revisit that comment. It was inadequate for me at 37.5mg, many with milder depressions may benefit from it, however if i were to given the option i would not use this drug in severe depression. I read a lot of comments on french website doctissimo which reflected a similar concern over efficacy.
Said it before, will say it again. A good anxiolytic. Reading this topic actually roused my interest and i just popped one. A bit naughty since i'm on another antidepressant but there aren't ANY interactions as far as i know and i'm still depressed since it's day 15 of treatment. Also watch out for insomnia. Increased by connection with natural world (strange but true).
Posted by West on December 21, 2008, at 7:13:53
In reply to Re: Stablon (Tianeptine) vs. SSRIs, posted by West on December 21, 2008, at 7:12:18
This is the end of the thread.
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