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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by halcyondaze on February 19, 2007, at 14:30:44
Good for them.
<< http://psychcentral.com/blog/archives/2007/02/18/glaxosmithkline-clinical-trial-register/ >>
Posted by halcyondaze on February 19, 2007, at 14:46:11
In reply to GlaxoSmithKline and Studies Available to Public, posted by halcyondaze on February 19, 2007, at 14:30:44
<< http://ctr.gsk.co.uk/Summary/tranylcypromine/I_004.pdf >>
Seems like Parnate US has a better bioavailability than Parnate Canada. I would LOVE to see this study with generics and UK brands.
I never even saw this published; perhaps they declined to publish it?
Posted by Phillipa on February 19, 2007, at 14:57:27
In reply to A Parnate Canada vs. Parnate US Study!, posted by halcyondaze on February 19, 2007, at 14:46:11
Only companies seem to publish what they want us to see. Love Phillipa
Posted by Larry Hoover on February 19, 2007, at 15:18:53
In reply to A Parnate Canada vs. Parnate US Study!, posted by halcyondaze on February 19, 2007, at 14:46:11
> << http://ctr.gsk.co.uk/Summary/tranylcypromine/I_004.pdf >>
>
> Seems like Parnate US has a better bioavailability than Parnate Canada. I would LOVE to see this study with generics and UK brands.
>
> I never even saw this published; perhaps they declined to publish it?I think there would be no reason to publish it. The U.S. product had a larger standard deviation than did the Canadian product on every parameter except time to peak plasma concentration. If you take into account that variability, the advantage (if any) of the U.S. product is virtually negated. The only way I could imagine it would make a difference is if an American took to buying from a Canadian source, but I still don't know if it would matter very much.
Lar
Posted by Quintal on February 19, 2007, at 16:04:42
In reply to GlaxoSmithKline and Studies Available to Public, posted by halcyondaze on February 19, 2007, at 14:30:44
"Female subjects must be post menopausal or surgically sterilized"
Seems excessively cautious.
Q
Posted by halcyondaze on February 19, 2007, at 17:18:28
In reply to Re: GlaxoSmithKline and Studies Available to Public, posted by Quintal on February 19, 2007, at 16:04:42
> "Female subjects must be post menopausal or surgically sterilized"
>
> Seems excessively cautious.
>
> QMost studies - especially studies sponsored by pharm companies - have this as an exclusion criteria, unless the drug has been proven beyond doubt not to cause birth defects and to be safe in all stages of pregnancy. At the very least, they require any females of child bearing age to have weekly pregnancy tests and to drop out of the study if they become pregnant.
Posted by Quintal on February 19, 2007, at 18:33:03
In reply to Re: GlaxoSmithKline and Studies Available to Public, posted by halcyondaze on February 19, 2007, at 17:18:28
I didn't know that. Why can't they stipulate women of childbearing age use an oral contraceptive for the duration of the study? I suppose birth control hormones might alter metabolism in some way that would affect treatment outcomes - estrogens also have antidepressant properties themselves so I've read which might lead to improved efficiency when combined with an antidpressant, so that would alter the result? (I'm not familiar with the language of clinical study but I guess there's a term for what I just described?):o)
Q
Posted by blueberry1 on February 20, 2007, at 15:46:17
In reply to GlaxoSmithKline and Studies Available to Public, posted by halcyondaze on February 19, 2007, at 14:30:44
Interesting studies on lamictal. A couple patterns I noticed. For people who do respond to lamictal for depression, it begins to happen by day 4. It seems to peak at about 6 to 8 weeks. No further gains after that. Also interesting was that there was practically no difference between 50mg and 200mg in efficacy.
Posted by Chairman_MAO on February 20, 2007, at 16:22:44
In reply to A Parnate Canada vs. Parnate US Study!, posted by halcyondaze on February 19, 2007, at 14:46:11
I used to order my own tranylcypromine hcl powder from a chemical company, as it was cheaper than buying the drug and worked just as well.
Posted by Quintal on February 20, 2007, at 16:28:17
In reply to Re: GlaxoSmithKline and Studies Available to Public, posted by blueberry1 on February 20, 2007, at 15:46:17
I didn't respond to lamotrigine until about two months after taking the first dose. We only have appointments with our pdocs every 2-3 months here at the most and I was about to give it up at my next appointment when I noticed my mood started to get much brighter and had actually been much more stable for a few weeks though I hadn't noticed that at the time. I wouldn't give up on lamotrigine after 4 days. You can't reasonably expect to assess it's true potential after such a short ime.
Q
This is the end of the thread.
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