Posted by desolationrower on March 25, 2011, at 6:29:46
In reply to Please explain agomelatine action on 5HT?, posted by Franz on March 4, 2011, at 10:21:36
> Hello, Doc suggested switching from escitalopram 10 mg to agomelatine.
>
> It is very expensive so I have to evaluate it.agomelatine seems to be bit faster working than some other drugs. the best way to know is spend a week or three with it.
> As I understand it enhances melatonin "reception" or sensitivity. When I used melatonin to sleep I had nightmares. Will this happen with agomelatine?
maybe, maybe not. the 5ht2c antagonism should decrease time spent in REM so there should be less 'dreaming' than with pure melatonin.
> The supposed (I read articles negating this) 5-HT2C receptor antagonism affects serotonin?. How does this compare to escitalopram. Can this also have an anti obsessive effect?serotonin=5ht. ssris are blunt, whereas blocking a certain receptor is a more specific effect. this can be good or bad; it can avoid side effects, or not do the useful thing you need. I think there is some evidence on 5ht2c in OCD though most looks at 5ht2a.
> Is the structure of agomelatine similar to tianeptine?
>probably just to the extent that is needed to be sorta kind like 5ht and so effect various things 5ht intereacts with.
> Thanks and sorry for all the quesations.
>
>-d/r
Better living through chemistry, socialism, and big phallic rockets (with a side of roquette)
poster:desolationrower
thread:980083
URL: http://www.dr-bob.org/babble/neuro/20100607/msgs/981092.html