Posted by Brainbeard on May 25, 2010, at 7:12:25
In reply to Alternatives to amisulpride, posted by Paul Forsyth on May 4, 2010, at 5:28:04
The question is what makes amisulpride work for you: is it its preferential stimulation of dopamine autoreceptors at low doses? In that case, an alternative could be low dose flupentixol (0.5mg a day), BUT flupentixol can also be sedating. But if so, you could also simply lower the dose, since amisulpride does that trick even in doses of less than 25mg.
If it's the D2 antagonism helping you out, low dose pipamperone might be another option: it can work well together with an SSRI, presumably because of 5HT2-antagonism, and may be enough of an antipsychotic to replace amisulpride. It MAY be less sedating than amisulpride..
Finally, modafinil may be a very good idea, since it works synergistically with amisulpride in my experience and can do a good job of keeping you awake when you should be.
Current meds: 10mg melitracene + 0.5mg flupentixol; sertraline 100mg; amitriptyline 25mg; gabapentin (Neurontin) 300mg; melatonin 0.3mg. PRN: diazepam (Valium) 2.5-5mg.
poster:Brainbeard
thread:946236
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/948753.html