Posted by Brainbeard on April 14, 2010, at 13:47:58
In reply to Re: Technical question on new anti-depressant, posted by Katgirl on April 7, 2010, at 10:08:24
5ht3 receptors facilitate dopamine release, so blocking them has an antidopaminergic effect. I think this has been missing from the info offered thus far. This antidopaminergic effect may have potential for alleviating OCD symptoms, as well as for countering the reward mechanism of addictions. (Ondansetron, a 5ht3-antagonist, has been investigated for both options. Ondansetron has a very short half-life, which complicates the use of the drug for such purposes. Memantine is also a 5ht3-antagonist, among other things.)
poster:Brainbeard
thread:942527
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/943374.html