Posted by Helena24 on March 23, 2010, at 16:55:07
Hi,(sorry for my bad English).
I'm currently on 10 mg Strattera and experiencing strong dysphoria (wich I'm managing with diazepam and Tianeptine).A few years ago I startet taking 40 mg Stattera but I had to quit shortly due to extreme somnolence and irritability.
I have ADD and depression.
Now I learnt that a second metabolite of atomoxetine is a partial agonist on the kappa opioid receptor (the stimulation of it is thought to decrease dopamine function in the striatum).
Could the dysphoria be because of this action?
I have been on desipramine bevore and it didn't cause dyspohoria (it's not available were I live).
I never tried reboxetine.
Is there someone who took both ,Strattera and Reboxetine ,a tell if this two drugs work differently?Is a ''low dopamine deep limbic ADD'' (sorry if this is not a scientifical term) be worsened by a kappa agonism due to antidopaminergic action?
Could this be linked to the suicidility that Strattera sometimes causes?
I feel a stronger need to take more Tianeptine since I am on Strattera.Maybe because I need my dopamine function restored?
Thoughts?
poster:Helena24
thread:940600
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/940600.html