Posted by linkadge on March 19, 2010, at 6:55:29 [reposted on March 23, 2010, at 0:34:55 | original URL]
The antidepressant citalopram decreases cb1 cannabanoid function while the tricyclic antidepressants appear to increase it.
http://www.springerlink.com/content/2127100x043n3674/
Conclusions These data provide evidence for reduced cannabinoid receptor-mediated G-protein coupling in the hypothalamus, hippocampus and medial geniculate nucleus of rats chronically treated with citalopram, effects which may, in part, underlie the mechanism of action of SSRIs.
http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=219
Three-week administration of the tricyclic antidepressant desipramine resulted in a significant increase in the density of CB1 receptors in certain brain areas (hippocampus and hypothalamus) without significantly altering endocannabinoid levels. The reduction of stress-induced corticosterone secretion by the antidepressant was blocked by a CB1 receptor antagonist
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