Posted by West on February 6, 2010, at 8:25:53 [reposted on February 22, 2010, at 1:38:35 | original URL]
In reply to Re: correct link » West, posted by conundrum on February 6, 2010, at 6:50:40
>> I'm curious if it increases norepinephrine how it decreases constipation. Maybe it blocks some other adrenergic receptors as well.
That didn't occur to me. a-antagonists decrease NE release and inhibit the NE system as a whole/decreasing sympathetic tone/lowering blood pressure and create a (relative) state of hypotension. It would be interesting to what the clinical effect of a combined catecholaminergic/anticatecholaminergic drug would be. i would have thought that antagonzing a-receptors would produce undesirable effects in depression, but who knows? Guanfacine, an a-2 antagonist, has both diarrhea and constipation as listed side-effects.
>>i see holeUnfortunately Savella isn't FDA approved for the treatement of depression in the U.S. It is only approved for fibro/cfs. I guess U of O want their creation approved for depression.
Ken Gilman, of psycotropical, among others seems to see 1:1, NE:5-HT, as the hold grail. i personally find that a bit much. I agree that NE plays a crucial role though.
poster:West
thread:937616
URL: http://www.dr-bob.org/babble/neuro/20091104/msgs/937653.html