Posted by bulldog2 on February 6, 2010, at 12:16:08 [reposted on February 22, 2010, at 1:20:57 | original URL]
In reply to Re: Dopamine not the magic answer folks, posted by linkadge on February 6, 2010, at 10:26:44
> I don't know where this whole idea of dopamine being the magic cure comes from. So many people come on this board and say "I've got a dopamine problem because I have yadi-yada symptoms".
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> Fist off, there are virtually no AD's that target dopamine. Wellbutrin (contrary to popular belief) has only very weak effects on the dopamine transporter.
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> Mirapex is also not a miracle antidepressant.
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> Animals studies also show that if you increase dopamine in the pleasure centres of the brain it activates BDNF in that area. BDNF in the neucleus accumbens produces behavioral depression.
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> Long term admistration of many drugs of abuse often increases feelings of craving and of depression.
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> You can block the behavioral depressant effects of accumbal dopamine by administering antipsychotics. This is why antipsychotics probably have a better record of being adjuncts for depression than do stimulants.
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> D3 receptor activation likely produces the depressant effects as mice lacking the d3 receptor do not respond this way to dopaminergic drugs.
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> Infact mice that have been administered dopamine precursors or dopaminergic drugs behave like they have been defeated in social models of depression. Serotonin on the other hand facilitates social dominance.
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> There is a difference between pleasure and an antidepressant effect. For instance, smoking weed. Sure you get a hit, then you just feel like a looser.
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> Linkadge
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> We need drugs that address dopamine. Maybe that is the missing link. We address the other two neurotransmitters so why not dopamine? I believe it is because of the fear of addiction because of its connection to pleasure.Read and enjoy
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>http://www.webmd.com/depression/news/20050728/dopamine-may-play-new-role-in-depression
http://www.acnp.org/g4/GN401000093/CH.html
http://www.utexas.edu/research/asrec/dopamine.html
http://www.news-medical.net/news/2008/01/16/34383.aspx
http://www.primarypsychiatry.com/aspx/articledetail.aspx?articleid=1525
http://www.primarypsychiatry.com/aspx/articledetail.aspx?articleid=1525
http://depression.about.com/cs/brainchem101/a/brainchemistry_2.htm
http://www.ncbi.nlm.nih.gov/pubmed/16051151
http://www.journals.elsevierhealth.com/periodicals/bps/article/PIIS0006322305012436/abstract
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thread:937616
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