Posted by Brainbeard on January 2, 2010, at 14:51:37
In reply to Re: 'Prozac not potent (...)' - Yes it is! » Brainbeard, posted by mtdewcmu on December 31, 2009, at 11:36:24
> What do you make of this statement?
>
> "It should be noted that the blockage of 5HT transporters and that of 5HT2C receptors would have opposing actions on serotonergic synaptic transmission."
>
> It would seem that Prozac's effects on 5-HT2C may cancel each other out.It's interesting. But time is an important factor. Normally, SRI will cause indirect agonism of all 5HT receptors including 5HT2C receptors. Indirect 5HT2C-agonism causes instant anorexia, for one thing. But when time passes by, there is a downregulation of 5HT2C receptors, so in the end indirect 5HT2C-agonism may have similar results as 5HT2C-antagonism. I suspect that this is the reason for the long-term side-effect of weight gain with SSRI's.
Anyway, because of the non-linear dose/response relationship of 5HT2C-antagonism, i.e. only a little is enough to reach significant effects, with low dose Prozac the indirect 5HT2C-agonism would probably be too weak to interfere much with the 5HT2C-antagonism.
poster:Brainbeard
thread:927037
URL: http://www.dr-bob.org/babble/neuro/20091104/msgs/932152.html