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Re: Need help trying to 're-create' Geodon's effects.. » bulldog2

Posted by delna on November 2, 2009, at 4:29:55

In reply to Re: Need help trying to 're-create' Geodon's effects.. » delna, posted by bulldog2 on November 1, 2009, at 14:40:54

> Antagonists
> Dimebon (non-selective)[21]
> Fluoxetine[5]
> FR-260,010: high affinity, selective over 5-HT2A and many other receptors; orally active.[22]
> RS-102,221: 100-fold selectivity compared to the 5-HT2A and -HT2B receptor subtypes[23]
> SDZ SER-082: mixed 5-HT2B/2C antagonist
> SB-200,646: mixed 5-HT2B/2C antagonist
> SB-206,553: mixed 5-HT2B/2C antagonist
> SB-221,284: mixed 5-HT2B/2C antagonist
> SB-242,084[24]
> compound 15k: IC50 = 0.5 nM; >2000x selective over 5-HT1A, 5-HT-2A, and 5-HT-6, and dopamine D2D4 receptors[25]
> agomelatine
> methysergide
> mirtazapine
> risperidone
> O-Desmethyltramadol (an active metabolite of tramadol, with considerable mu-opiate agonism)
>
> Well here's a list of some 5HT2C-antagonists

Thanks for the all your research and for the list! I really appreciate it!
Of all those, the only ones I know/ can get hold of are: agomelatine,methysergide, mirtazapine, risperidone and fluoxetine.

methysergide- I don't think this has any AD or anti-OCD properties at all. So I can't really use it as my main serotonin influencing drug

mirtazapine- yes, I have thought of this drug seriously, especially in combination with effexor, but it is very, very sedating.

risperidone- I can't take AP's since I may have developed TD on Geodon.

agomelatine- This is not available in India yet plus it doesn't have very strong 5ht2c binding. I am not sure about its other properties.

> How about substituting effexor (since it worked) for prozac

Effexor worked in that it switched me into mania. I don't know if it will work to activate me, if it can't switch me (because of my mood-stabilizer). Someone who is very close to me is taking it and she is finding that it makes her sleepy. We have really similar chemistries and drug reactions (but then we do share a strong genetic link).

> and risperidone (can you tolerate that) in your combo
AP's are not currently an option.

Thanks again for your input
TC
Love
D

 

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poster:delna thread:923807
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