Posted by zzzz7 on June 22, 2009, at 6:14:23
In reply to Clomipramine vs Amitryptaline, posted by Meltingpot on May 17, 2009, at 11:25:34
It hits the H1 receptor really hard. Also anticholinergic effects are strong.
It's a great anti-depressant. There is, of course, a difference between fatigue and depression. (Fwiw, amil. is pretty sedating, as well, usually even more so than is clom.)
I had the kind of fatigue you describe on clom. I was taking 400mg, though. I stuck with it because it worked so well for me against my depression.
If you can't live with the fatigue, you might try adding something to it, maybe an SSRI at a tiny low dose and dialing down the TCA slowly and dialing up the SSRI slowly. E.g. you might try adding 5mg Celexa to it, and go to 20mg Celexa slowly while going down to 50mg clomipramine.
poster:zzzz7
thread:896239
URL: http://www.dr-bob.org/babble/neuro/20090129/msgs/902585.html