Posted by morganpmiller on June 5, 2009, at 23:17:28
In reply to Re: Do SSRI's cause dopamine depletion » sowhysosad, posted by SLS on May 20, 2009, at 5:46:21
Hi I'm new to this board. You guys know that Zoloft is a Serotonin and Dopamine reuptake inhibitor, especially at doses of 100 and more?
Re: Zoloft and dopamine reuptake inhibition
Posted by halcyondaze on January 19, 2007, at 21:44:16
In reply to Zoloft and dopamine reuptake inhibition, posted by Quintal on January 19, 2007, at 21:12:03
> I've been reading for a while that Zoloft is a mild dopamine reuptake inhibitor. Can anyone comment on how powerful a DA reuptake inhibitor it is with reference to others such as Ritalin, Wellbutrin etc.?
>
> Has anyone noticed important differences between Zoloft and other SSRIs that could be attributed to DA reuptake inhibition?
>
> My main memories from the last trial of this med were appalling nausea and vomiting with diarrhea and genital anaesthesia. Any similar?
>
> I'm attracted by the Zoloft packaging - I like the idea of his little smiley face looking out at me at every morning:
>
> http://upload.wikimedia.org/wikipedia/en/3/33/Zoloft_logo.png
>
> QIt has far more dopamine reuptake inhibition than Wellbutrin. I have a chart from "Psychiatry Second Edition Therapeutics" by Wiley Publishing (editor: Alan Tasman) which is basically like a psychiatry Bible, with affinity (which equals 10^-7 x 1/Kd, where Kd equals the dissociation constant) and here are the numbers:
Serzone: approximately 0.3
Wellbutrin: approximately 0.2
Paxil: approximately 0.2
Zoloft: exactly 4.0
... with a bunch of the tricyclics and Prozac at less than 0.1.It is amazing, if you see the chart. Zoloft is over four times more potent in terms of DA reuptake inhibition than any of the others.
Post #1
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I snagged these off the internet. Figured many would find these useful/interesting. I didn't take the pics, wish they were a little bit clearer.<< http://i2.photobucket.com/albums/y32/tygereyes83/Book.jpg >>
1) RELATIVE AFFINITIES OF ANTIDEPRESSANTS FOR BLOCKING MUSCARINIC RECEPTORS
<< http://i2.photobucket.com/albums/y32/tyger.../Muscarinic.jpg >>
2) RELATIVE AFFINITIES OF ANTIDEPRESSANTS FOR BLOCKING HISTAMINIC RECEPTORS
<< http://i2.photobucket.com/albums/y32/tyger.../Histaminic.jpg >>
3) RELATIVE AFFINITIES OF ANTIDEPRESSANTS FOR BLOCKING THE REUPTAKE OF NOREPINEPHRINE
<< http://i2.photobucket.com/albums/y32/tyger.../NEreuptake.jpg >>
4) RELATIVE AFFINITIES OF ANTIDEPRESSANTS FOR BLOCKING ALPHA1ADRENORECEPTORS
<< http://i2.photobucket.com/albums/y32/tyger...lpha1adreno.jpg >>
5) RELATIVE AFFINITIES OF ANTIDEPRESSANTS FOR BLOCKING THE REUPTAKE OF SEROTONIN
<< http://i2.photobucket.com/albums/y32/tyger...uptakeblock.jpg >>
6) RELATIVE AFFINITIES OF ANTIDEPRESSANTS FOR BLOCKING 5HT-2A RECEPTORS
<< http://i2.photobucket.com/albums/y32/tyger...ceptorblock.jpg >>
7) RELATIVE AFFINITIES OF ANTIDEPRESSANTS FOR BLOCKING THE REUPTAKE OF DOPAMINE
<< http://i2.photobucket.com/albums/y32/tyger...uptakeblock.jpg >>
8) RELATIVE AFFINITIES OF ANTIDEPRESSANTS FOR BLOCKING DOPAMINE RECEPTORS
<< http://i2.photobucket.com/albums/y32/tyger...ceptorblock.jpg >>
poster:morganpmiller
thread:883495
URL: http://www.dr-bob.org/babble/neuro/20090129/msgs/899619.html