Posted by SLS on June 5, 2009, at 17:42:35
In reply to Receptors that desipramine affect + ADD-I, posted by TriedEveryDrug on June 5, 2009, at 11:38:11
Hi.
Imipramine had been used in the 1980s for adult ADD. It might have enough 5-HT inhibition to mitigate the dysphoria and anxiety you are experiencing. Of course, imipramine is converted extensively in the body into desipramine.
What I would do in place of switching from desipramine to another drug would be to combine it with things that target the dysphoria and anxiety. It would be interesting to run an experiment and try taking Zyprexa for a few days to see if both the dysphoria and anxiety resolve. If they do, at least you know that such a thing is possible and that you can begin to look for a substitute.
You should post your question on the Medication board too. Linkadge is usually good at knowing the receptors that are affected by different drugs.
By the way, it seems that desipramine and Strattera actually produce an increase in the concentrations in diffuse interstitial dopamine. Under normal circumstances the NET is responsible for clearing this residual dopamine as it occurs in the frontal cortical regions. I'm sure you can figure out the rest.
- Scott
poster:SLS
thread:899532
URL: http://www.dr-bob.org/babble/neuro/20090129/msgs/899567.html