Posted by Meltingpot on June 4, 2009, at 11:27:55
Hi,
I am hoping that somebody will be able to explain the below paragraph to me. Does this mean that the dopamine transporter on the Presynaptic neurone takes up the serotonin rather than the 5HT transporter which is being blocked by the SSRI?
If this is the case wouldn't that negate the effects of the SSRIs?
I get a bit confused by the indirect affects of antidepressants and I'm trying to get my head around it all.
thanks.........Denise
Now, however, Fu-Ming Zhou (presently at the University of Tennessee) and colleagues at Baylor College of Medicine have revealed that SSRIs can have more complex effects on neurotransmitter traffic in the brain than just altering serotonin levels. They found that higher serotonin concentrations caused by SSRIs can "trick" transporters of another key neurotransmitter, dopamine, into retrieving serotonin into dopamine vesicles. Dopamine transporters have a low affinity for serotonin, but the higher serotonin levels result in its uptake by the dopamine transporters, found the scientists.
poster:Meltingpot
thread:899383
URL: http://www.dr-bob.org/babble/neuro/20090129/msgs/899383.html