Posted by Meltingpot on May 17, 2009, at 11:35:34
Hi,
In the last 8 years by some flukey quirk of fate I've only responded to 40mg of Seroxat and then it stopped working after 2 years. I've since been unable to recapture the feeling.
As I've tried adding a lot of different meds to seroxat to no avail, around 12 weeks ago I decided to try clomipramine partly because I read on this board that clomipramine has the highest affinity for 5HT after Seroxat.
Now clomipramine at 150mg does seem to help the depression/anxiety a bit but it is also making me really, really tired all of the time. Therefore I don't think it is working that well. When the seroxat worked for me I had an increase in energy and could stay up later and needed less sleep.
I'm now trying to kid myself or reassure myself that the one good thing that might come out of this trial and other trials is that if I stay off all SSRIs for a year then maybe I could go back on Seroxat at the beginning of next year and have it work again. However, I know that there is no evidence to suggest that this would be the case.
My question is, do tricyclics drugs affect exactly the same 5HT pre-synaptic receptors as SSRIS and do all SSRIs hit the same 5HT pre-synaptic receptors.
My thinking (grasping for ideas) is that if I have a complete break from SSRIs for a year and take tricyclics or MAOIs instead then after a year maybe I could go back on Seroxat and have it work for me again.
I'm not sure what else to do anymore, I'm just looking for some hope and some ideas.
Denise
poster:Meltingpot
thread:896245
URL: http://www.dr-bob.org/babble/neuro/20090129/msgs/896245.html