Posted by Crotale on June 20, 2008, at 13:23:26
In reply to selegiline + NAC, posted by iforgotmypassword on June 5, 2008, at 11:01:07
> both neuroprotective of the brains' dopaminergic capacity i gather, since NAC protects against meth damage. i will be able to protect my brain against any extra dopamine my therapies may release in my CNS.
I believe I've heard of NAC being used as a protective agent against the potential liver damage from overdosage of APAP/paracetamol, but not as a neuroprotective. When you say meth are you referring to selegiline's L-methamphetamine metabolite?
> i may do the opioid thing... which i want to. my luck there, at least right now, may not look so good. but i likely want to do both. i just cannot pick between naltrexone and buprenorphine for my doctor. i feel quite guilty asking, as in canada, buprenorphine is a VERY NEW drug, was heavily publicized as being a replacement for methadone.
I wish you good luck. I've had lots of problems in the US since BUP started being used for maintenance treatment; doctors have misinterpreted the Drug Addiction Treatment Act of 2000 (I started taking it in, I think, 1998) and assumed they needed a waiver to prescribe Buprenex for depression (they don't). I've found it very effective for depression. I've heard of it being used with success for atypical depression and so-called "personality disorders" too.
Don't feel guilty: I don't think docs can get in trouble for prescribing it. I recommend bringing them the Callaway editorial, "Buprenorphine for Depression: the Unadoptable Orphan," which discusses why there hasn't been more research on BUP for depression.
I used the references for the Bodkin et al. 1995 article from J Clin Psychophparm as a source of other articles on opioids in depression, then went to the local medical school library to get copies for my doctor. If you have access to a medical library that's what I'd suggest you do. Some of them, of course, are online, but some of the older ones, in particular, might be hard to find. The McLean group only studied a small group, but the article is useful because of the detailed discussion of the patients' responses.
Again, best of luck to you.
poster:Crotale
thread:833090
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/835641.html