Posted by rgb on June 2, 2008, at 17:44:35
In reply to 5HT2a stuff » undopaminergic, posted by iforgotmypassword on June 2, 2008, at 8:30:03
Sorry, I don't have a direct answer, but note that the psychedelic 5-HT2A agonists affect the receptor in a different way than other agonists; IIRC it's something about different conformational changes and activation of different second messengers (BTW, of which kind is serotonin? Presumably non-psychedelic, but OTOH this would be odd considering the structural similarity of serotonin and psilocin/DMT/and so on)
On a related note, I'm not sure I agree with the general idea here that 5-HT2A is bad for motivation. Psilocybin tended to induce feelings of child-like genuine fascination and meaningfulness in me. This "higher-level" effect might actually be more important than the catecholamines, don't know. Sub-psychedelic doses could possibly be useful against my current apathy, but getting this done would be such a hassle.
poster:rgb
thread:831008
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/832561.html