Posted by undopaminergic on May 22, 2008, at 10:09:34
In reply to Sulpiride and Abilify questions..., posted by michael on May 17, 2008, at 23:01:23
I think aripiprazole (Abilify, APZ) is regarded as a full agonist at presynaptic dopamine (DA) (auto)receptors. This reduces DA synthesis and release, and is likely to be contrary to what you're looking for. Therfore, if sulpiride were to antagonise binding of APZ to autoreceptors, it would be expected to counter the sedative potential of the latter (APZ) and thus enhance stimulation. At higher doses, sulpiride might possibly block the partial agonism of APZ at postsynaptic DA receptors, and thus nullify the usefulness of the latter for dopaminergic enhancement.
In practice, you will have to test to determine the usefulness of the combination.
poster:undopaminergic
thread:829749
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/830476.html