Posted by bleauberry on May 13, 2008, at 17:32:27 [reposted on May 16, 2008, at 4:08:18 | original URL]
In reply to mechism of action of norepinephrine selective ADs, posted by John Doughboy on May 13, 2008, at 13:59:44
Good questions! I wish I had the answers. Someone here probably has some good explanations.
As you said, things are complicated. For example, while it generally thought that NE/DA is related to anhedonia/energy and such, there are people who get lethargic and anhedonic instead. While a lot of us seem to get dull and numbed on SSRIs, there are some people who just come to life full of joy and emotion.
I can understand how acute NE or DA can boost energy or mood in many people, but how it works on a chronic basis I have no idea. Surely feedback loops must kick in, receptors reregulate one way or the other, downstream effects are put into motion, and of course it is impossible to affect one neurotransmitter system without indirectly impacting the others. Way over my head.
poster:bleauberry
thread:828910
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/829376.html