Posted by John Doughboy on May 11, 2008, at 16:03:28
In reply to Re: Zolft helps OCD but doesn't help depression » John Doughboy, posted by johnj on May 11, 2008, at 12:58:33
I don't think Effexor (or Prestiq) is going to be my choice because I don't want more serotonin reuptake inhibition than I'm getting now on Zoloft at 100 mg. To get anything noticeable in the norepinephrine department, I would have to get even more serotonin because of venlafaxine's fixed serotonin/norepinephrine ratio. (Drugs with more than one AD mechanism of action might be convenient,but are hard to fine tune compared to two selective drugs.)
And trying Luvox: it's just another SSRI. To me all SSRI are more or less the same; they all are extremely selective for serotonin and bind to exactly the same pre-synaptic 5H-T sites-only differences are in widely varying halflifes and slighlty different metabolic pathyway
So it seems my only practical choice is adding on Wellbutrin XL (it's a shame that amineptine is no longer on the market).
poster:John Doughboy
thread:828365
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/828531.html