Posted by undopaminergic on May 7, 2008, at 21:43:59
In reply to Re: How does NE affect anxiety?, posted by bleauberry on May 6, 2008, at 18:44:48
>
> Of all the anti-anxiety meds...klonopin, xanax, zyprexa, seroquel, lexapro, paxil, zoloft, remeron...these actually weren't that good for me and in some cases made it worse. The ones that were real good were Milnacipran and Nortriptyline, both fairly strong NE reuptake inhibitors. My hypothetical take is that with the shored up NE, feedback loops kicked in and slowed down the release of more NE. They sensed enough NE was already there and to slow down making more, with the resulting calm. While the brain, its links to cortisol and hormones, and psychiatry are way too complicated to understand or explain, that is just my simple take on it.
>Have you tried guanfacine? It would be a good test for your theory, as it stimulates alpha2-adrenergic receptors, which (among other things) function as presynaptic autoreceptors that inhibits the release and synthesis of noradrenaline.
poster:undopaminergic
thread:827297
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/827843.html