Posted by rgb on March 10, 2008, at 10:54:39
In reply to Agomelatin, posted by Markwell on March 4, 2008, at 7:46:54
Sorry, can't answer your question directly, but just a thought on agomelatine:
Wikipedia specifically says that it's a 5-HT2C antagonist. If it's really selective for 5-HT2C as opposed to 5-HT2A, this would be a quite interesting add-on to an SSRI. In my dilettantish understanding, 5-HT2C is the main culprit in dopamine inhibition; correct me if I'm wrong. Unfortunately, all other 5-HT2C antagonists I know also block histamine and/or dopamine. I also wouldn't like to antagonize 5-HT2A.
Are there any legal ways of obtaining "no-mans-land" compounds like this? I hope this isn't against the rules, feel free to delete this last paragraph otherwise :)
poster:rgb
thread:816089
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/817069.html