Posted by kingcolon on February 24, 2008, at 12:06:36
In reply to Re: Salvia and kappa-opioids., posted by Dopamine123 on February 23, 2008, at 14:10:49
> Buprenorphine is supposed to have antidepressant properties.
> http://opioids.com/buprenorphine/buprefdep.html
>
> It is a partial mu-opioid agonist and a kappa-opioid antagonist. The kappa-opioid antagonist property may explain part of its antidepressant effect. That drug might be worth a try.With all due respect, I just made this point a few posts back. And I would once again add that I'm on bupe and it has worked wonderfully for my rather treatment-resistant depression. The Bodkin article is a "classic" and I've found little in the way of trials other than his. Here is an article of interest that talks about cognitive deficits in people on buprenorphine and methadone.
I've noticed no problem--in fact, my attention and insight seems better on bupe.http://www.biomedcentral.com/1472-6904/7/5#B56
If anyone would like a copy of the full Bodkin study, I have it--you can get to me by kingcolon.
poster:kingcolon
thread:808350
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/814424.html