Posted by undopaminergic on July 3, 2021, at 3:37:35
In reply to Mirtazapine worked so well for me,but liver issues, posted by TriedEveryMedication on July 2, 2021, at 10:01:49
>
> My pdoc thinks it was maybe the 5-HT2C action what was helpful. I looked for other drugs that are antagonists for this and couldn't find much. Mianserin is very similar to mirtazapine and probably has the same liver issues.
>
> So anyway, my questions:
>
> Do you think my psych is right that the 5-HT2C action in MIRT is what is helpful?
>In my view, it is not unlikely, because serotonin 5-HT2C antagonism enhances dopamine release.
> And if so, are there any alternatives that might be more liver friendly?
>Asenapine may be the strongest 5-HT2C antagonist available. It is structurally related to mianserin though, and so may provoke the same reaction as mirtazapine.
Another 5-HT2C antagonist is agomelatine (Valdoxan), and sertindole (Serdolect) is an inverse agonist.
-undopaminergic
poster:undopaminergic
thread:1115756
URL: http://www.dr-bob.org/babble/20210418/msgs/1115764.html