Posted by linkadge on August 5, 2019, at 8:37:09
In reply to Re: Microdosing! » linkadge, posted by pedr on August 4, 2019, at 10:15:23
Yes, I have read this before. In animals, for example, serotonergic antidepressants reduce the 'head twitch' response to LSD and other psychedelics. It's a bit counterintuitive, as you would think a serotonin drug would enhance a serotonin agonist.
I think part of the mechanism of SSRIs is to downregulate or desensitize the 5-ht2 receptor system. However, LSD is also a non-specific dopamine agonist and this effect might still be in play if somebody is taking an SSRI.
Linkadge
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thread:1105547
URL: http://www.dr-bob.org/babble/20190728/msgs/1105624.html