Posted by TriedEveryMedication on June 25, 2018, at 20:24:59
In reply to Re: any drugs with strong NRI action ?, posted by linkadge on June 25, 2018, at 15:40:10
> The Ki doesn't matter that much.
>
> The ki just tells the drug's effect at a certain concentration. The concentration is a function of the metabolism of the drug and the dose.
>
> In other words, with perhaps a higher dose of protriptyline, you are going to get the same NRI effect.
>
> You may not need a higher dose, however, if protriptyline is better absorbed, or has a longer half life.
>
>
> LinkadgeSo in theory, if desipramine works for me, atomoxetine should work for me with the right dose?
Unfortunately, this hasn't been my experience.
poster:TriedEveryMedication
thread:1099300
URL: http://www.dr-bob.org/babble/20180521/msgs/1099302.html