Posted by bleauberry on March 25, 2018, at 6:01:46
In reply to Re: Lyme disease - a neuropsychiatric disease » bleauberry, posted by SLS on March 24, 2018, at 8:37:11
SLS I have some great chapters in books with immense information - both traditional and scientific - on Cordyceps. In the coming days if I can I will try to gather together some of the main highlights as it pertains to psychiatry.
So Doxy did nothing but Mino had a good response in 3 days. I doubt anyone on earth can actually explain that but I think I have a reasonable hypothesis.
Borellia is a tricky bacteria, intelligent, with the ability to morph itself into 3 different forms. Within minutes of exposure to danger, such as a hot immune system or antibiotics, they switch into either the L form or the cystic form. Whichever of the two forms they switch into - and they can do this literally in minutes to hours - the different forms are not susceptible to the same antibiotics.
For example Doxy is effective against the main form of Borellia, but not the cystic form. It could be that as soon as you started dosing Doxy, they morphed, and the Doxy was no longer the right choice. In simple terms, it is more wide spectrum than Doxy is.
But Mino is different. It has the ability to do things that Doxy cannot do. Tetracycline - Doxy's dad - is also different than either, and has characteristics unique to it. Mino has been used in other longterm protocols unrelated to lyme, for cell-wall deficient bacteria and other obscure things that Doxy is not appropriate for.
When a suspected lyme patient starts treatment, there is a short window of "feeling better than in a long time" which usually happens between day 2 and day 5. It sounds like that may have happened with you on day 3.
But it is more complicated than that. I am not aware of any patients who ever got better on any single antibiotic. In every case, other than acute cases, it has required multiple antibiotics to cover the spectrum of potential pathogens we will never be able to successfully test for, and these antibiotics are usually switched out and traded for other ones on a monthly or bimonthly basis - this is why any clinical trials on the subject as worthless - the clinical trials do not in any way duplicate real actions in the clinical setting.
So I would hypothesize that in your body Doxy did not hit a target but Mino did. My journeys have taught me that the benefits of Mino in terms of psychiatry accrue over months and even years, not days or weeks. The 3-day thing you experienced was - in my opinion - a clue that you were on the right path.
It's all detective work. We have to search for hints and clues and try to make sense of them. The Doxy/Mino thing you experienced offers clues.
> Dr. Bransfield has not yet begun to follow your protocol. I'll ask him the next time I see him as to why not. He will, on certain patients, utilize doxycycline based on clinical presentation and not biological tests... just in case Lyme or some other tick-borne disease is involved. It was the first thing he added to my regime while we began to formulate a plan for the use of psychiatric medications. It was interesting that 3 months of doxycycline had no effect on my disease state while minocycline improved my depression within 3 days. How would you explain this? Anti-bacterial (inhibit protein synthesis)? Intrinsic anti-inflammatory activity in the brain (microglia)? Glutamatergic activity modulation (glutamate release)? The two drugs are not the same. Two people aren't the same. I definitely wouldn't generalize that minocycline is just another tetracycline class antibiotic. If doxycycline doesn't help, minocycline might.
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poster:bleauberry
thread:1097634
URL: http://www.dr-bob.org/babble/20180212/msgs/1097679.html