Posted by linkadge on October 8, 2017, at 15:15:54
In reply to Re: Trintellix...Weaker SRI?, posted by phidippus on October 8, 2017, at 14:36:36
Yeah, it's actually got a couple of mechanisms which make it interesting.
It is a 5-ht1a agonist and 5-ht1b agonist.
Both of these have antidepressant effects. 5-ht1b agonists probably have even more antidepressant and anti-OCD effects than 5-ht1a agonists (5-ht1a agonists being more effective for anxiety).It is a 5-ht1d antagonist, which might offset some of the negative hormonal effects of the SSRI effect (i.e. grown hormone blunting).
It is a 5-ht3 antagonist, which might contribute to anti-anxiety effects, and offset SSRI nausea.
And, as SLS mentions, it is a 5-ht7 antagonist - which can have faster acting antidepressant effects (especially in changing depression associated sleep changes).
poster:linkadge
thread:1095290
URL: http://www.dr-bob.org/babble/20161215/msgs/1095333.html