Posted by SLS on October 23, 2016, at 12:07:28
In reply to Re: NSI-189 » cakethread, posted by TriedEveryMedication on October 23, 2016, at 11:25:31
> Ketamine seems very promising, but my doctor says it has to be slowly infused for it to work right.
Yes. When using ketamine IV, the dose is administered at a rate of 0.5 mg/kg over 40-minutes.
Ketamine *can* work just fine intranasally. Unfortunately, it had no effect on me. The only two other people I know of who tried it achieved remission and have maintained it for several years. One of them doses herself once every 5 days. The dose can be finessed by counting the number of inhalations performed. However, if one fails to respond to intranasal administration, one might still respond well to IV. I opted for intranasal to try first simply because of its convenience. You know within a week if it is going to work, so you aren't really wasting much time by trying it first.
I would like to emphasize that NMDA receptor antagonism is *not* necessary for ketamine or similar such drugs to exert an antidepressant effect. The focus on NMDA has been a bit of a distraction. The real site of action is AMPA glutamatergic neurons. In fact if you block AMPA receptors, ketamine doesn't work.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1092714
URL: http://www.dr-bob.org/babble/20160928/msgs/1092730.html