Posted by SLS on August 3, 2016, at 1:09:09
In reply to Re: orthomolecular, posted by Hello321 on August 2, 2016, at 19:34:31
Has Periactin stopped working entirely? How long did it work for, and at what dosage? Was it sedating? I am considering using Periactin it myself. Thank you.
Periactin (cyproheptadine) is a 5-HT2a/b/c receptor antagonist. I believe that Remeron and nefazodone are 5-HTa/c antagonists. I'm thinking that if Remeron and nefazodone are without effect, perhaps it is important that you get some 5-HT2b action going on. Trintellix (vortioxetine) is a partial agonist, so it might act to stabilize 5-HT2b activity. If it is necessary to get all three 5-HT2a/b/c, you might have to take Remeron to complement Trintellix. Unfortunately, a pure 5-HTa/b/c antagonist named ritanserin is not available, even though it is perfectly safe. Of course, there may be other of properties of Periactin that made you feel better.
I am not suggesting that you give up all of your other therapeutic experiments (pharmaceutical or nutriceutical). However, I would keep Trintellix (possibly with Remeron or nefazodone) in mind if you have not yet tried it.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1090994
URL: http://www.dr-bob.org/babble/20160713/msgs/1091121.html