Posted by g_g_g_unit on April 27, 2016, at 4:22:36
In reply to Re: Brintellix question, posted by jonhed on April 27, 2016, at 4:02:03
> Am i wrong or isn't every substance that acts as a antagonist, regardless if we talk about noradrenalin, serotonin or dopamine, in risk of causing akathisia, just to a bigger or smaller extent?
>
> Or is the risk smaller if it also, as brintellix does, act as a partial agonist?
>
> I'm to interested in knowing that because i have said no in over a year to brintellix due to the fact that i already have some sorts of chronic akathisia from being over-medicated when i was younger. (it got to the point when my mom filed a report to the doctor, so it's an extreme case, these things doesn't happen alot think)I'm not sure. Noradrenaline antagonists (I guess you could throw beta-blockers, Prazosin etc. into that category) never induced akathisia in me. Dopamine antagonists certainly did.
I had akathisia that lasted for a year after discontinuing Mirtazapine. It was awful.
5-HT1a agonists and 5-ht3 antagonists both increase dopamine (and improve Parkinson's symptoms), but I can't find any evidence they would improve akathisia. My doctor is very pushy; I suppose if I try it, I would have to tread cautious and discontinue at any signs of its emergence.
poster:g_g_g_unit
thread:1088472
URL: http://www.dr-bob.org/babble/20160331/msgs/1088502.html