Posted by ed_uk2010 on January 18, 2015, at 10:10:09
In reply to Re: Mutiple mechanism with Zyprexa and some atypicals, posted by Lamdage22 on January 18, 2015, at 9:22:59
>How is Saphris'es side effect profile compared to Seroquel, Zyprexa and amisulpride?
Efficacy and side effects are both relevant, but I'm not especially familiar with asenapine (Saphris, Sycrest) to be honest. It's infrequently used here. It was rejected in the EU as a treatment for schizophrenia/psychosis because the studies which were submitted were not sufficient to convince the European Medicines Agency that it was an effective treatment. It showed some efficacy in acute mania, and was approved for this purpose only.
Trials of asenapine have tended to be very short. It is therefore difficult to assess its long-term impact on weight with any certainty. I expect it causes a similar amount of weight gain to Risperdal. Less than Zyprexa but more than amisulpride.
Zyprexa and amisulpride have been pretty consistent in showing good results in the treatment of psychosis. Zyprexa has also been studied for mania and proven effective. Amisulpride hasn't been studied much for bipolar mania.
Efficacy data for Seroquel are reasonable in psychosis, but it's probably less effective than Zyprexa or amisulpride, and the drop out rate seems highest with Seroquel. Seroquel does not seem more effective than typical antipsychotics in schizophrenia. Seroquel has shown useful effects as an add-on in depressive states, however, and as monotherapy in some cases of bipolar depression.
poster:ed_uk2010
thread:1074889
URL: http://www.dr-bob.org/babble/20150102/msgs/1075231.html