Posted by SLS on December 30, 2014, at 14:26:26
In reply to cymbalta, posted by joe f on December 30, 2014, at 13:02:04
> even though Cymbalta has norephrinephrine for many it is not activating...any thoughts
It is tricky to try to predict the behavior of a drug in real life based upon what is observed in the laboratory or the theories offered by researchers. Often, a new property will be discovered for an old drug that which comes to explain inconsistencies in previous theories. Nortriptyline, a drug that was categorized primarily as a norepinephrine reuptake inhibitor was found to be soporific and anxiolytic in some people. As technology and understanding grew, it was found that nortriptyline was also a potent serotonin 5-HT2a antagonist.
Even if we were able to offer a guess about Cymbalta based upon a simple model, it is important to note that Cymbalta is at least 10 times stronger as a reuptake inhibitor of serotonin than of norepinephrine.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1074590
URL: http://www.dr-bob.org/babble/20141120/msgs/1074596.html