Posted by SLS on May 9, 2014, at 14:19:08
In reply to Re: Brintellix Trial 10mg. @Eric, Scott, Lamdage22 » SLS, posted by jrbecker76 on May 9, 2014, at 9:48:36
Hi JRB.
> Hi Scott,
>
> Just curious when you had the opportunity to try Idazoxan. Was it in a clinical trial?1992 at the National Institutes of Health - NIMH. It made my depression significantly worse. This is also true of Remeron, Latuda, and Saphris. Latuda was worse than Saphris.
I really went to the NIMH so that I could be treated with clorgyline (irreversible specific MAO-A inhibitor). I hadn't anticipated 12 weeks of idazoxan hell in order to try it.
> I've come to the conclusion that alpha-2 NE activity might also be counterproductive for me. Just my hunch given certain reactions (i.e., irritability, agitation) I've had to drugs that hit that profile (e.g., Mirtazapine, Seroquel). I've wanted to do a trial with Yohimbine just to confirm it, but I think this would be confounded by the fact that Yohimbine has affinity for 5-HT1b as well which would also probably contribute to its deleterious effects.I didn't know that Seroquel or any of its metabolites were NE alpha-2 antagonists. Science discovers new properties of old drugs all of the time.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1061746
URL: http://www.dr-bob.org/babble/20140419/msgs/1065426.html