Posted by LouisianaSportsman on May 1, 2014, at 21:13:50
In reply to ^^ Above Post is for Klein-- this is about Aptiom, posted by LouisianaSportsman on May 1, 2014, at 20:11:56
Ah! Forgot about mirtazapine!
Let's see which ones work with which assuming that Brintellix stays no matter what.
Aptiom (eslicarbazepine) 800mg.
Brintellix (vortioxetine) 20mg
Dexedrine (dexamphetamine) 60mg.
Latuda (lurasidone) 60mg.
(Pamelor (notriptyline) 75mg./ Desipramine 100mg.)
(Remeron (mirtazapine 45mg.)
((Oleptro ER (trazadone) 300mg.))
Trodenki XR (topiramate) 200mg.
Klonopin (clonazepan) 1.5mg.We have it built around
Brintellix (vortioxetine):
Serotonin reuptake inhibitor = 1.6 nM
NET blocker = 113 nM
5-HT1A receptor near-full agonist = 15 nM
5-HT1B receptor partial agonist Ki = 33 nM
5-HT1D receptor antagonist Ki = 54 nM
5-HT3A receptor antagonist Ki = 3.7 nM
5-HT7 receptor antagonist Ki = 19 nMMirtazapine:
SERT: no appreciable affinity
5-HT1A receptor= 18 nM
5-HT2A receptor= 69 nM
5-HT2C receptor= 39 nM(inverse agonist)Desipramine:
SERT Inhibtion: 179 nM
NET: 2.27 nMNortriptyline:
SERT: 16.5 nM
NET: 1.65 nM
5-HT2A: 43 nM
5-HT2C: 8.5 nMTrazadone:
SERT: 367.3 nM
5-HT2A: 35.8 nM
5-HT2B: 78.4 nMBased on my analysis, nortriptyline looks risky to add to Brintellix and Trazadone whereas desipramine and mirtazapine, in particular, would not be likely to cause issues and would go very good with the MOA of the trazadone.
poster:LouisianaSportsman
thread:1065010
URL: http://www.dr-bob.org/babble/20140419/msgs/1065074.html