Posted by doxogenic boy on October 22, 2013, at 12:39:49
In reply to Bipolar Depression and Antidepressants, posted by SLS on October 21, 2013, at 19:46:10
>Randomized studies by this editor Post et al. and Vieta et al. have shown that venlafaxine is more likely to bring about switches into mania than other types of antidepressants such as bupropion or selective serotonin reuptake inhibitors (SSRIs).
Here is a study with the opposite results:
http://www.ncbi.nlm.nih.gov/pubmed/19694630Acta Psychiatr Scand. 2010 Mar;121(3):201-8. Epub 2009 Aug 19.
Venlafaxine monotherapy in bipolar type II depressed patients unresponsive to prior lithium monotherapy.
Amsterdam JD, Wang G, Shults J.Depression Research Unit, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. [email protected]
Abstract
OBJECTIVE:We examine the safety and efficacy of venlafaxine monotherapy in bipolar type II (BP II) patients with major depressive episode (MDE) who were unresponsive to prior lithium monotherapy. We hypothesized that venlafaxine would be superior to lithium with a low hypomanic conversion rate.
METHOD:Seventeen patients who were unresponsive to prior lithium monotherapy were crossed to venlafaxine monotherapy for 12 weeks. The primary outcome was within-subject change in total Hamilton Depression Rating (HAM-D) score over time. Secondary outcomes included the change in Young Mania Rating (YMRS) and clinical global impressions severity (CGI/S) and change (CGI/C) scores.
RESULTS:Venlafaxine produced significantly greater reductions in HAM-D (P < 0.0005), CGI/S (P < 0.0005), and CGI/C (P < 0.0005) scores vs. prior lithium. There was no difference in mean YMRS scores between treatment conditions (P = 0.179).
CONCLUSION:Venlafaxine monotherapy may be a safe and effective monotherapy of BP II MDE with a low hypomanic conversion rate in lithium non-responders.
- doxogenic
Earlier TRD/anxiety
300 mg tianeptine, 6 X 50 mg successfully since Oct 2009
20 mcg liothyronine
40 mg escitalopram
100 mg trimipramine
50 mg agomelatine
600 mg quetiapine
poster:doxogenic boy
thread:1052718
URL: http://www.dr-bob.org/babble/20130930/msgs/1052783.html