Posted by SLS on July 21, 2013, at 22:27:42
In reply to Re: Ketamine...whoa!, posted by poser938 on July 21, 2013, at 21:06:04
> Ketamine did the same thing for me that Dextromethorphan in cough syrup did. Both just made me dizzy and neither had any effect on my mood. But, my brain isn't in the right way of functioning to be responding to meds correctly, due to some long-term effects from past meds.
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> I tried it in a range of doses since my psychiatrist had prescribed it in intranasal take-home form.Are you able to take the ketamine as a series of micro-doses over the course of a half hour? Right now, I am doubtful that IM or intranasal administrations can replicate the IV protocol: 0.5 mg/kg over 40 minutes.
You are not alone in having a brain that has been made less responsive to treatment as the result of prior exposures to psychotropic drugs. This is also my reality. It is likely to be the reality of a great many of the people posting here. Not good.
Each of us must try to sort out the truths of his existence as best he can. That our early exposures to psychiatry's primitive tools led to persistent changes in brain function is one of these truths. It is what it is. It is only the year 2013. This is too early in the evolution of medical science to expect anything better. We want treatments that help more and hurt less. Perhaps ketamine represents a clue as to how this may be accomplished. However, it is really more of an heuristic tool than a workable therapy. I guess administering a series of ketamine treatments while continuing standard antidepressant therapy would have the best chance of producing a remission. Maintenance ketamine treatments could be used if necessary. 10 years from now, we might have an oral form of a drug that produces results similar to IV ketamine treatment, but targets a different site on the NMDA receptor. There are virtually no psychotomimetic side effects. If this drug produces rapid sprouting and strengthening of neuronal dendritic spines like ketamine does, we might have a winner. We'll see.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1047574
URL: http://www.dr-bob.org/babble/20130706/msgs/1047591.html