Posted by vanvog on March 22, 2013, at 10:39:51
In reply to Re: Parnate Therapeutic Effect and MAOI Inhibition, posted by vanvog on March 21, 2013, at 16:27:57
I found a few more references in Psychotropic Drug Handbook 8e by Paul J. Perry, Bruce Alexander, Barry Liskow and C. Lindsay DeVane
"It is estimated that tranylcypromine 0.7 mg/kg per day equals phenelzine 1.0 mg/kg per day (Grasso, Perry, & Sherman, 1991)."
http://www.ncbi.nlm.nih.gov/pubmed/2008794
"A positive correlation exists between the degree of platelet MAO inhibition and clinical response for phenelzine ans isocarboaxid, but not necessarily tranylcypromine (Giller, 1980)" I couldn't find the study this part refers to.
"With a dose of phenelzine 60 mg/day for 6 weeks, 68% of patients with MAO inhibition greater than 80% responded favorably; 79% improved with greater than 90% inhibition. However, the response rate was only 44% in those achieving less than 80% inhibition, and the placebo improvement rate was only 32% (Robinson et al., 1978)
http://www.ncbi.nlm.nih.gov/pubmed/365127"[...] doses of phenelzine of 1 mg/kg per day and tranylcypromine of 0,7 mg/kg per day in most patients will usually produce the 80% or greater MAO inhibition necessary to attain an antidepressant response."
poster:vanvog
thread:1040654
URL: http://www.dr-bob.org/babble/20130322/msgs/1040875.html